摘要
目的探讨宁波地区女性生殖道支原体属感染现状及支原体属感染与不孕之间关系,及支原体属对抗菌药物的耐药特点,为临床治疗支原体属感染合理选择抗菌药物提供实验室依据。方法对在医院就诊的门诊和住院的1593例女性患者的生殖道分泌物标本进行支原体属的培养和药敏试验,支原体属检测采用法国生物梅里埃公司生产的IST试剂盒进行检测。结果 1593例女性患者中,共检测出支原体属787株,阳性率为49.4%,感染以解脲脲支原体(Uu)为主,占86.8%;361例不孕症女性阴道分泌物中分离出211株支原体属,阳性检出率为57.4%;药敏试验结果显示,普那霉素、交沙霉素、多西环素、四环素对Uu的抗菌活性最强,敏感率分别为99.4%、97.5%、97.5%和95.5%;喹诺酮类抗菌活性最弱;环丙沙星、左氧氟沙星的耐药率分别为83.2%和70.4%;人支原体(Mh)的耐药率均高于解脲脲支原体,特别是对大环内酯类抗菌药物,其耐药率高达83.3%。结论女性生殖道支原体属感染呈上升趋势,因此临床上合理应用抗菌药物和正确的治疗对降低抗菌药物耐药率,防止治疗后的复发具有非常重要的意义;女性生殖道支原体属感染是引起流产和不孕症的主要原因,由支原体属引起的流产和不孕症是可逆的,治愈后仍有机会恢复生育。
OBJECTIVE To explore the current status of the female genital tract mycoplasma infection and the relationship between mycoplasma infection and infertility.And mycoplasma drug resistance to antimicrobial drugs for clinical treatment of mycoplasma infection in a reasonable choice to provide laboratory evidence of antimicrobial agents.METHODS In our hospital outpatient and 1593 hospitalized patients with female genital tract specimens were cultured and susceptibility testing of mycoplasma and mycoplasma by the French company′s IST bioMérieux kit for testing.RESULTS Totally 1593 female patients were detected out of mycoplasma（Uu,Mh） 787 cases,the positive rate was 49.4%,mainly infected by UU,the total number detected in 84.8%;361 cases of female infertility,vaginal discharge 211 strains of mycoplasma isolated positive rate was 57.4%.Susceptibility test results show that pristinamycin,josamycin,doxycycline,tetracycline antibacterial activity against most Uu,sensitivity rates were 99.4%,97.5%,97.5% and 95.5%;quinoline antibacterial activity of the ketones Here weak;ciprofloxacin,levofloxacin resistance rates were 83.2% and 70.4%.Resistant Mycoplasma hominis Ureaplasma urealyticum was higher than that,especially macrolide antibiotics,the resistance rate of 83.3%.CONCLUSION Female genital mycoplasma infection is rising,therefore rational use of antimicrobial drugs in clinical treatment and the right treatment to reduce rates of antibiotic resistance,to prevent relapse after treatment is significant.Female genital infection is the main cause abortion and infertility,miscarriage caused by the mycoplasma and infertility is reversible,there is still opportunity to restore fertility after cure.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第20期4401-4403,共3页
Chinese Journal of Nosocomiology
关键词
支原体属
女性
不孕症
耐药率
Mycoplasma
Female
Infertility
Drug resistance rate
