摘要
目的:观察肠肺清颗粒结合机械通气治疗急性呼吸窘迫综合征(ARDS)的疗效。方法:38例予机械通气ARDS患者分为观察组和对照组两组,每组19例,对照组采用常规治疗,观察组在常规治疗的基础上加用肠肺清颗粒鼻饲治疗,比较两组的血气指标、氧合指数(PaO2/FiO2)、肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)、APACHEⅡ评分及病死率。结果:两组治疗后pH、PaCO2、PaO2/FiO2均较治疗前明显升高(P<0.05),观察组治疗后PaO2/FiO2明显高于对照组(P<0.05);两组治疗后血浆TNF-α、IL-8水平均较治疗前明显降低(P<0.05),观察组治疗后TNF-α明显低于对照组(P<0.05);治疗后观察组、对照组APACHEⅡ评分均明显低于治疗前(P<0.05),观察组治疗后A-PACHEⅡ评分明显低于对照组(P<0.05);观察组、对照组病死率分别为31.58%(6/19)、57.89%(11/19),差异无统计学意义(P>0.05)。结论:肠肺清颗粒能够降低TNF-α等细胞因子的产生和释放;改善ARDS患者的氧合指数,降低ARDS病死率。
Objective： To observe the effect of Changfeiqing granule combined with mechanical ventilation on acute respiratory distress syndrome （ARDS）. Methods： A total of 38 ARDS patients with mechanical ventilation were randomly divided into observation group and control group by half. Patients in control group were treated by conventional treatment, while patients in observation group were treated by Changfeiqing granule by nasal feeding plus conventional treatment. The blood gas indexes, PaO2/FiO2, TNF-α, IL-8 and mortality were observed, APACHE Ⅱ score was also performed. Results： The levels of pH, PaCO2, PaO2/TiO2 were significantly increased（P〈0. 05）, while TNF-α, IL-8 and APACHE Ⅱ score were significantly decreased after treatment （P〈 0. 05）. The level of PaO2/FiO2 was significantly higher and TNF-α and APACHE Ⅱ score were significantly lower in observation group than that of control group （P〈0.05）. The mortality was 31.58% （6/19） in observation group and 57.89%（11/19）in control group, and there was no significant difference between two groups（P〉0. 05）. Oonclusions： Changfeiqing granule can reduce the production and release of cytokines such as TNF-α, improve oxygenation index, and decline mortality in ARDS.
出处
《海南医学院学报》
CAS
2011年第11期1506-1509,共4页
Journal of Hainan Medical University
基金
海南医学院科研基金资助学报项目(0020110415)~~
