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万古霉素及利奈唑胺对金黄色葡萄球菌耐药性的临床研究 被引量:4

Effects and safety of linezolid and vancomyc for patients with MRSA-related pneumonia
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摘要 目的:比较抗生素利奈唑胺与万古霉素治疗耐甲氧西林金黄色葡萄球菌MRSA肺炎的临床疗效及安全性。方法:对38例接受万古霉素治疗和40例接受利奈唑胺治疗的老年MRSA肺炎患者的临床治愈率、细菌清除率及不良反应发生率等进行比较。结果:利奈唑胺组治愈率为72.7%,细菌清除率为81.8%,不良反应发生率为10%;万古霉素组治愈率为78.8%,细菌清除率为86.7%,不良反应发生率为11%。两组治愈率、细菌清除率及不良反应发生率无明显差异(P>0.05)。结论:利奈唑胺组和万古霉素治疗老年MRSA肺炎临床疗效相似,可安全地应用于老年患者。 Objective To compare the clinical therapeutics and medication safety of linezolid (ox- azolidinonantibacterial) and ancomyc in patients with Methicillin-resistant Staphylococcus aureus (MR- SA)-related pneumonia. Methods= The cure rate, bacterium clearance rate and adverse-effect incidence of ratein vancomyc group (n= 38 patients) and linezlid group (n= 40 patients) were observed and compared. Results Cure rate, bacterium clearance rate and 72.7%, 81.8%, and 10% for the vancomyc group. Conclusion Vancomycin and linezolid shows equal effects against MRSA-related pneumonia with great safety and well-tolerance for elderly patients.
出处 《海南医学院学报》 CAS 2011年第11期1504-1505,1509,共3页 Journal of Hainan Medical University
基金 海南医学院科研基金资助学报项目(0020110414)~~
关键词 利奈唑胺 万古霉素 金黄色葡萄球菌 MRSA肺炎 老年人 Linezolid Vancomyc Staphylococcus aureus MRSA-related pneumonia Elderly patients
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