摘要
目的研究高度近视眼近视弧形态与近视性眼底病变发生的关系,为临床上早期发现近视性眼底病变提供形态学上的参考。方法回顾性分析高度近视眼25例46眼患者黄斑光学相干断层扫描图像(optical coherence tomography,OCT)、吲哚青绿血管造影(indocyanine green angiography,ICGA)、视力等资料,将单纯漆纹样裂纹改变眼设为A组(5例10眼);出现近视性眼底病变眼为B组(17例30眼;包括A组);无近视性眼底病变眼为C组(8例16眼);分析3组近视弧类型、近视弧面积、白色脉络膜萎缩弧面积、白色脉络膜萎缩弧与近视弧面积比、黄斑部视网膜厚度、黄斑部视网膜体积等形态学变化。结果 A组、B组、C组矫正远视力分别为0.45±0.29、0.34±0.25、0.82±0.22,A、B组与C组比较,差异均有统计学意义(均为P<0.05)。A、B2组近视弧形态各方面比较差异均无统计学意义。B、C组比较:近视弧面积比较差异有统计学意义(P=0.030),95%可信区间分别是5.85～8.45mm2、2.67～6.79mm2;白色脉络膜萎缩弧面积比较差异有统计学意义(P=0.010),95%可信区间分别是2.03～4.04mm2、0.08～2.07mm2;白色脉络膜萎缩弧与近视弧面积比比较差异也有显著统计学意义(P=0.000),95%可信区间分别为0.28～0.47、0.00～0.25。75%(24/32)环形弧眼、82.7%白色脉络膜萎缩弧眼出现近视性眼底病变。A、B、C3组黄斑区视网膜厚度、黄斑部视网膜体积差异均无统计学意义(均为P>0.05)。结论近视性眼底病变明显影响视力;近视弧面积超过5.85mm2,白色脉络膜萎缩弧面积达到2.00mm2且与近视弧面积比超过0.28以上,白色脉络膜萎缩弧、环形弧的出现,均应警惕近视性眼底病变的发生。
Objective To study the correlation of peripapillary crescent shape with fundus disease in high myopia,and provide the features of peripapillary crescent shape in fundus disease of high myopia.Methods The fundus imaging of three dimensional optical coherence tomography（3D-OCT）,indocyanine green angiography（ICGA） features,visual acuity of 46 eyes with high myopia were retrospectively analyzed.All eyes were divided into three groups,eyes with lacquer crack alone in group A（5 cases,10 eyes）,fundus diseases of myopia in group B（17 cases,30 eyes）,no fundus diseases of myopia in group C（8 cases,16 eyes）.The peripapillary crescent type,peripapillary crescent area,choroidal atrophy crescent area,ratio of choroidal atrophy crescent area to peripapillary crescent area,macular retinal thickness and volume were analyzed.Results The corrected distant visual acuity in group A,B,C were 0.45±0.29,0.34±0.25 and 0.82±0.22,respectively,compared with group C,there were statistical differences of group A and B（all P0.05）.There was no statistical difference in myopia peripapillary crescent shape between group A and B.Compared between group B and C,there was statistical difference in myopia peripapillary crescent area（P=0.030）,the 95% confidence interval（CI） was from 5.85 mm2 to 8.45 mm2 in group B and from 2.67 mm2 to 6.79 mm2 in group C;There were statistical difference in choroidal atrophy crescent area（P=0.010）,95% CI was from 2.03 mm2 to 4.04 mm2 in group B and from 0.08 mm2 to 2.07 mm2 in group C;There was significant difference in ratio of choroidal atrophy crescent area to peripapillary crescent area（P=0.000）,95% CI was from 0.28 to 0.47 in group B and from 0.00 to 0.25 in group C.Myopia fundus diseases happened in 24 cases（75.0%） with ring peripapillary crescent and 24 cases（82.7%） with choroidal atrophy crescent.There was no statistical difference in macular retinal thickness and volume among group A,B and C（all P0.05）.Conclusion Fundus disease of high myopia affect the visual acuity;If the ring peripapillary crescent area is more than 5.85 mm2,choroidal atrophy crescent area reaches 2.00 mm2,ratio of choroidal atrophy crescent area to peripapillary crescent area is more than 0.08,the fundus disease of high myopia should be cared.
出处
《眼科新进展》
CAS
北大核心
2011年第9期842-845,共4页
Recent Advances in Ophthalmology
关键词
近视弧
近视性眼底病变
吲哚青绿血管造影
三维光学相干断层扫描
peripapillary crescent
fundus disease of myopia
indocyanine green angiography
three dimensional optical coherence tomography
