摘要
目的观察全身热疗联合化疗对中晚期肺癌患者的近期疗效及安全性。方法回顾性分析中晚期肺癌患者128例,分为单纯化疗组(A组)和化疗联合全身热疗组(B组),其中A组64例,给予多西他赛注射液75 mg/m2,d1,顺铂注射液30 mg/m2,d1～32,个周期;B组64例采用同样方案化疗,第1天同时给予深度镇静全身热疗,使全身温度升至40℃～42℃,维持90 min,2个周期;观察A组和B组患者的近期疗效及毒副作用。结果 A组中完全缓解(CR)0例,部分缓解(PR)33例,稳定(SD)17例,进展(PD)14例,有效率(CR+PR)为51.6%;B组中CR 3例,PR 50例,SD 7例,PD 4例,CR+PR为82.8%;两组比较,差异有统计学意义(P=0.01)。Ⅲ～Ⅳ度肝、肾功能损害、骨髓抑制及消化道反应发生率A组分别为7.8%、14.0%及20.3%;B组分别为10.9%、10.9%及23.4%,差异均无统计学意义(P=0.15)。结论全身热疗联合化疗治疗中晚期肺癌的疗效确切,毒副作用轻,耐受良好,值得临床推广。
Objective To determine the shorterm efficacy and security of whole body hyperthermia（WBH） combined with chemotherapy for advanced lung cancer.Methods Patients with advanced lung cancer were treated by chemotherapy alone（64 patients,group A） or chemotherapy combined with whole body hyperthermia（64 patients,group B） from October,2007 to October,2010.Two cycles of chemotherapy including docetaxel 75 mg/m2 in d1 and cisplatin 30 mg/ m2 in d1~3 were given to all patients,whereas WBH was given to the patients in the group B in the first day of the first cycle of chemotherapy,and the whole body temperature was maintained at 40℃~42℃ for 90 min.Results In Group A,the rate of compele remission（CR） was 0 patient,partial remission（PR） 33 patients,stable disease（SD）17 patients,progressive disease（PD） 14 patients and the overal response rate（CR＋PR） was 51.6%;while in Group B,the corresponding figures were 3,50,7,4 and 82.8%,respectively.There were significant difference between the two groups（P=0.01）.The rate of Ⅲ°﹢Ⅳ°abnormal liver and kidney function,myelosuppression and gastrointestinal tract were 7.8%、14.0% and 20.3% in Group A;while 10.9%、10.9% and 23.4% in Group B.No significant difference was found between them（P=0.15）.Couclusion IWBH combined with chemotherapy is efficient and safe for advanced lung cancer.
出处
《实用癌症杂志》
2011年第5期483-485,共3页
The Practical Journal of Cancer
关键词
全身热疗
化学治疗
肺癌
Whole body hyperthermia
Chemotherapy
Lung cancer
