摘要
目的:探讨血管细胞黏附分子-1(VCAM-1)、甚晚抗原-4(VLA-4)在特应性皮炎(AD)皮损中的表达及意义。方法:采用免疫组化法检测26例AD患者皮损VCAM-1、VLA-4的表达,参照欧洲AD评分标准(SCORAD)对病情严重程度进行评分,分析VCAM-1、VLA-4的表达水平与病情严重程度的相关性。结果:AD患者组皮损VCAM-1、VLA-4的平均光密度(AOD)明显高于正常对照组(P<0.05),VCAM-1、VLA-4的表达水平与SCORAD评分呈正相关(P<0.05)。结论:AD患者皮损VCAM-1、VLA-4的表达增高,VCAM-1、VLA-4的表达水平可作为反映病情严重程度的指标。
Objective To investigate the expressions and significances of vascular cell adhesion molecule-1 （VCAM-1） and very late antigen-4 （VLA-4） in the lesion of atopic dermatitis （AD）.Methods Immunohistochemical method was used to measure the expressions of VCAM-1 and VLA-4 in the lesion from 26 patients with AD,and SCORAD was used to grade the severity of AD.The correlation between the severity and the levels of VCAM-1 and VLA-4 was identified.Results The average optical density （AOD） of VCAM-1 and VLA-4 in the lesion of patients with AD was significantly higher than that in the control group （P 0.05）.The levels of VCAM-1 and VLA-4 was positively correlated with the score of SCORAD （P 0.05）.Conclusions The expressions of VCAM-1 and VLA-4 in the lesion of patients with AD were increased,and may be the markers reflecting the severity of AD.
出处
《实用医学杂志》
CAS
北大核心
2011年第19期3515-3517,共3页
The Journal of Practical Medicine
基金
成都医学院立项成都医学院第一附属医院独立资助项目(编号:CYFY10DL-006)
