摘要
表面等离子体共振(SPR)生物传感器在生物大分子检测时具有非常高的理论分析精度,但在实际应用过程中传感响应特性容易受到环境温度的影响。在小型化SPR传感器中由于缺乏温度控制模块,这种情况尤为明显。利用理论模型分析研究了环境温度变化对传感系统中光源、棱镜、金属薄膜和待测溶液等不同介质、光学检测器等的物理特性的影响以及由此引起的传感响应曲线的变化。研究结果表明:随着温度的增加,传感响应曲线中共振角度会相应减小。这一研究为小型化SPR生物传感器的研究开发提供了重要依据。
Surface plasmon resonance （SPR） biosensor has very high theoretically analytical precision in the detection of biological macromolecules. However, in practical application, its responding characteristics are easily impacted by the environmental temperature. This case is more obvious in miniaturized device for temperature controlling module is not integrated in it. A theoretical mode is used to analyze the impact of the enviromnental temperature on the characteristics of the light source, prism, metal film, analyte solusion, and detector. The result shows that with the increase of temperature,resonance angle in the response crave will decrease accordingly. This study provides an important basis for the research and development of miniaturized SPR biosensor.
出处
《传感器与微系统》
CSCD
北大核心
2011年第10期69-71,74,共4页
Transducer and Microsystem Technologies
基金
国家自然科学基金资助项目(81071278)
重庆市科技计划资助项目(CSTC2009AB5081
CSTC2010AC5029)
教育部新世纪优秀人才支持计划资助项目(NCET-09-0842)
