期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

精神分裂症核心家系与脑源性神经营养因子基因C270T多态性研究 被引量：8

暂未订购
导出
摘要 目的研究脑源性神经营养因子(brain-derived neurotrophic factor,BNDF)基因C270T多态性与精神分裂症的关系。方法在91个精神分裂症核心家系中,以聚合酶链反应和限制性片段长度多态性的方法对BDNF基因C270T多态性进行检测。采用单体型相对风险(haplotype relative risk,HRR)和传递不平衡检验(transmission/disequilibrium test,TDT)对精神分裂症与BDNF基因C270T多态性位点进行关联分析,以及分析该位点与阳性和阴性症状量表(positive and negative syndrome scale,PANSS)各因子分的关系。结果 HRR分析显示,BDNF基因C270T多态性与精神分裂症无关联(掊2=3.39,P>0.05)。TDT分析未发现BDNF基因C270T多态性位点在精神分裂症患者中存在传递不平衡(掊2=3.2,P>0.05)。携带T等位基因(CT和TT基因型)的患者阳性症状分高于未携带T等位基因(CC基因型)的患者(t=-2.11,P=0.04)。结论本研究未发现BDNF基因C270T多态性和精神分裂症关联,但发现T等位基因可能与阳性症状存在关联。
作者 郭晓娟 亢万虎 郭丽阳
机构地区 西安市精神卫生中心康复科 西安交通大学附属医院精神科
出处 《中国神经精神疾病杂志》 CAS CSCD 北大核心 2011年第9期568-570,共3页 Chinese Journal of Nervous and Mental Diseases
关键词 精神分裂症 BDNF基因 C270T多态性 核心家系
分类号 R749.3 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献10

  • 1Buckley PF,Mahadik S,Pillai A,et al.Neurotrophins and schizophrenia[J].Schizophr Res,2007,94(1-3):1-11.
  • 2Kunugi H,Ueki A,Otsuka M,et al.A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease[J].Mol Psychiatry,2001,6(1):83-86.
  • 3Li W,Wei J,Zhou DF,et al.Lack of association between the BDNF C270T polymorphism and schizophrenia in a Chinese Han population[J].Schizophr Res,2007,97(1-3):297-298.
  • 4Galderisi S,Maj M,Kirkpatrick B,et al.COMT Val158Met and BDNF C270T polymorphisms in schizophrenia:a case-control study[J].Schizophr Res,2005,73(1):27-30.
  • 5Xu MQ,St Clair D,Ott J,et al.Brain-derived neurotrophic factor gene C-270T and Val66Met functional polymorphisms and risk of schizophrenia:A moderate-scale population-based study and meta-analysis[J].Schizophr Res,2007,91(1-3):6-13.
  • 6Zintzaras E.Brain-derived neurotrophic factor gene polymorphisms and schizophrenia:a meta-analysis[J].Psychiatr Genet,2007,17(2):69-75.
  • 7Szekeres G,Juhász A,Rimanóczy ?魣,et al.The C270T polymorphism of the brain-derived neurotrophic factor gene is associated with schizophrenia[J].Schizophr Res,2003,65(1):15-18.
  • 8何小林 ,赵靖平 ,刘铁桥 ,刘涛 ,张向晖 .脑源性神经营养因子基因C270T多态性与精神分裂症的关联研究[J].中国行为医学科学,2005,14(7):623-624. 被引量：11
  • 9Nanko S,Kunugi H,Hirasawa H,et al.Brain-derived neurotrophic factor gene and schizophrenia:polymorphism screening and association analysis[J].Schizophr Res,2003,62(3):281-283.
  • 10郭敬华,郭素芹,苏林雁,杜海霞,郭芳,李强,潘伟盟,常克萍.脑源性神经营养因子基因C270T多态性与儿童精神分裂症的关系[J].中国神经精神疾病杂志,2009,35(5):257-260. 被引量：6

二级参考文献22

  • 1何小林 ,赵靖平 ,刘铁桥 ,刘涛 ,张向晖 .脑源性神经营养因子基因C270T多态性与精神分裂症的关联研究[J].中国行为医学科学,2005,14(7):623-624. 被引量：11
  • 2Ashe PC,Berry MD,Boulton AA.Schizophrenia,a neurodegenerative disorder with neuredevelopmental antecedents[J].Prog Neuropsyehopharmacol Biol Psychiatry,2001,25(4):691 -707.
  • 3Zintzaras E.Brain-derived neuretrophic factor gene polymorphisms and schizophrenia:a meta-analysis[J].Psychiatr Genet,2007,17(2):69 -75.
  • 4Li W,Wei J,Zhou DF,et al.Lack of association between the BDNF C270T polymorphism and schizophrenia in a Chinese Han population[J].Schizophr Res,2007,97(1 -3):297-298.
  • 5Xu MQ,St-Clair D,Ott J,et al.Brain-derived neuretrophic factor gene C-270T and Va166Met functional polymorphisms and risk of schizophrenia:a mederate-scale population-based study and metaanalysis[J].Schizophr Res,2007,91 (1 -3):6-13.
  • 6Andreaeen NC,Oleen S.Negative v Positive schizophrenia:definition and validation[J].Arch Gen Psychiatry,1982,39(7):789-794.
  • 7Szekeres G,Juhasz A,Rimanoezy A,et al.The C270T polymorphism of the brain-derived neuretrophic factor gene is associated with schizophrenia[J].Schizophr Res,2003,65(1):15-18.
  • 8Eaatwoed SL.The synaptic pathology of schizophrenia:is aberrant neuredevelopment and plasticity to blame ? Int Rev Neurobiol,2004,59 (1):47-72.
  • 9Harrison PJ.The hippoearapus in schizophrenia:a review of the neuropathological evidence and its pathophysiological implications[J].Psycbepharmacology (Bed),2004,174(1):151-162.
  • 10Kibinska M,Hausor J,Czemki PM,et al.Association analysis of brain-derived neuretrephie factor (BDNF) gene Val 66 Met polymorphism in schizophrenia and bipolar affective disorder[J].World J Biol Psychiatry,2004,5(4):215 -220.

共引文献14

同被引文献111

  • 1马骏,王彦春,王述菊,程宇核,周冰,李娜.电针对阿尔茨海默病模型大鼠海马区神经营养因子及其受体表达的影响[J].针灸临床杂志,2010,26(7):63-66. 被引量：17
  • 2谭伟棠,刘涛,赵靖平.BDNF基因(GT)n二核苷酸重复多态与精神分裂症阴性亚型的关联研究[J].中华神经医学杂志,2005,4(10):1005-1006. 被引量：1
  • 3李永刚,谭云龙,周东丰,曹连元,杨甫德,张向阳,邹义壮,苏建民,姚付新,崔勇.长期治疗的慢性精神分裂症患者血清脑源性神经营养因子水平的研究[J].中国神经精神疾病杂志,2007,33(8):482-483. 被引量：12
  • 4汪向东，王希林，马弘，等．心理卫生评定量表手册[M]．北京：中国心理卫生杂志社，1999．
  • 5J.萨姆布鲁克,D.W.拉塞尔著.分子克隆实验指南[M].第3版.北京:科学出版社,2002.8,461-512.
  • 6Doherty J, O'Donovan M, Owen M. Recent genomic advances in schizophrenia[J]. Clin Genet, 2012,81 (2) : 103-109.
  • 7Kaymaz N, van Os J. Heritability of structural brain traits an endophenotype approach to deconstruct schizophrenia[J]. Int Rev Neurobiol, 2009,89 : 85-130.
  • 8Peper JS, Schnack HG, Brouwer RM, et al. Heritability of regional and global brain structure at the onset of puberty: a magnetic resonance imaging study in 9-year-old twin pairs[J]. Hum Brain Mapp, 2009,30(7) : 2184-2196.
  • 9Szekeres G, Juhasz A, Rimanoczy A, et al. The C270T polymor- phism of the brain-derived neurotrophic factor gene is associated with schizophrenia[J]. Schizophr Res, 2003,65 ( 1 ) : 15-18.
  • 10Sun RF, Zhu YS, Kuang WJ, et al. The G-712A polymor- phism of brain-derived neurotrophic factor is associated with major depression but not schizophrenia [ J ]. Neurosci Lett, 2011,489(1) : 34-37.

引证文献8

二级引证文献25

中国神经精神疾病杂志
2011年 第9期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部