摘要
报告1例少根根霉致皮肤接合菌病。患者男,76岁。因别嘌醇引起的大疱性表皮松解型药疹入院,治疗1周后右腮腺区出现坏死并迅速扩大。患者患高血压、多器官损害、糖尿病等。皮肤科检查:右腮腺区见7 cm×7 cm的皮肤干性坏死区。皮肤真菌镜检及组织病理PAS染色见大量宽大无分隔垂直分枝的菌丝。培养2 d即可见棉絮状的菌落生长。菌种鉴定为少根根霉。诊断为原发性皮肤接合菌病。虽给予两性霉素B脂质体静脉滴注及伊曲康唑口服、坏死组织清创术等积极治疗,但于感染的第18天死于急性冠脉综合征及肺出血。
A case of cutaneous zygomycosis caused by Rhizopus arrhizus is reported. A 76-year-old male with bullous epidermal necrolysis eruption caused by allopurinol represented with necrosis on his right parotid grand after one week＇s treatment. The lesion enlarged rapidly. He had high blood pressure, multiple organ damage, diabetes and so on. Dermatology examination showed an area of 7cm×7cm skin necrosis on his right parotid grand. Fungal examination and PAS staining of biopsy specimen revealed plenty of broad hyphae with branches in right angels and no septum. Fungal culture of the necrosis showed a cotton candy-like colony which was confirmed to Rhizopus arrhizus. The case was diagnosed as primary cuta- neous zygomycosis. The positive treatments were included using amphotericin B, itracanazole and surgical debridement. However, the patient died of acute coronary syndrome and pulmonary hemorrhage after 18 days of infection.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2011年第10期611-614,共4页
Journal of Clinical Dermatology
关键词
药疹
重症
少根根霉
接合菌病
皮肤
serious drug eruption
Rhizopus arrhizus
cutaneous zygomycosis
