摘要
脂联素（adiponectin，APN）是由脂肪细胞合成并分泌的一种血浆蛋白，在能量代谢、胰岛素抵抗、炎症反应及动脉粥样硬化的形成等生理病理过程中发挥重要的调节作用。研究显示，血浆脂联素水平在糖尿病、动脉粥样硬化及急性冠脉综合征患者明显降低，在慢性心力衰竭患者明显升高。
出处
《天津医科大学学报》
2011年第3期435-436,F0003,共3页
Journal of Tianjin Medical University
参考文献21
-
1Scherer PE, Willians S, Foglhno M, et al. A novel serum protein similar to Clq, produced exclusive|y in adipecytes [J]. J Biol Chem, 1995, 270(45): 26746.
-
2Skurk C, Wittehen F, Suckau L, et al. Description of a local cardiac adiponectin system and its deregulation in dilated cardiomyopathy [J]. Eur Heart J, 2008, 29(9):1168.
-
3Takano H, Obata JE, Kodama Y, et al. Adiponectin is released from the heart in patients with heart failure [J]. Int J Cardiol, 2009, 132 (2):221.
-
4Schraw T, Wang ZV, Halberg N, et al. Plasma adiponectin complexes have distinct biochemical characteristics [J]. Endocrinology, 2008, 149(5):2270.
-
5Trujillo ME, Scherer PE. Adiponectin-journey from an adipocyte secretory protein to biomarker of the metabolic' syndrome [J]. J Intern Med, 2005,257(2): 167.
-
6Fujioka D, Kawabata K, Saito Y, ct al. Role of adiponetin receptors in endothelin-induced hypertrophy in cultured eardiumyocytes and their expression in infracted heart [J]. Am J Physiol Heart Circ Physiol, 2006, 290(6): 2409.
-
7Ding G, Qin Q, He N, et al. Adiponectin and its receptors are expressed in adult ventrieular cardiomyocytes and upregulated by activation of peroxisome proliferators-aetivated receptor gamma[J]. J Mol Cell Cardiol, 2007, 43(1):73.
-
8Sehulze MB, Rimm EB, Shal 1, et al. Relationship between adiponectin and glycemic control, blood lipids and inflammatory markers in men with type 2 diabetes [J]. Diabetes Care, 2004, 27 (7): 1680.
-
9Ouedrango B, Wu X, Xu SQ, et al. Adiponectin suppression of high-glucose-indued reactive oxygen species in vascular endothelial cells: evidence for involvement of a cAMP signaling pathway [J]. Diabetes, 2006, 55(6):1840.
-
10Wang Y, Lain KS, Xu JY, et al. Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner [J]. Biol Chem, 2005, 280(18): 18341.
同被引文献7
-
1李小平,杨成悌,张灵,常鹏.高血压病患者血清脂联素水平的研究[J].中华心血管病杂志,2004,32(7):596-599. 被引量：37
-
2张鹏,汪南平.脂联素与心血管疾病[J].生理科学进展,2007,38(2):149-152. 被引量：9
-
3潘巍巍,江珊,于洪伟.心力衰竭患者血清脂联素水平与心功能的相关性研究[J].中国心血管病研究,2007,5(11):807-809. 被引量：7
-
4胡尔西旦.那斯尔,再吐娜.克里木.慢性心力衰竭患者血浆脂联素水平及其与代谢综合征的相关性[J].中国老年学杂志,2012,32(11):2250-2251. 被引量：7
-
5黄慧琳,冷吉燕,葛媛媛,付军.高血压患者血清脂联素与左心室肥厚及颈动脉粥样硬化的关系[J].中国老年学杂志,2012,32(13):2695-2697. 被引量：8
-
6林作天,黎雪玲,李醒三,盛瑞兰.原发性高血压患者血清脂联素水平的变化[J].中国老年学杂志,2012,32(13):2717-2718. 被引量：5
-
7吴穷,张凤如.脂联素对心力衰竭影响的研究进展[J].国际心血管病杂志,2012,39(5):269-271. 被引量：3
-
1卓志娟,雷鸣,夏先考.脂联素与心血管疾病的相关性[J].检验医学与临床,2012,9(23):2992-2994. 被引量：1
-
2田小飞,马玮娟,张键.脂肪因子Chemerin与非酒精性脂肪肝病的关系[J].公共卫生与预防医学,2015,26(2):75-78. 被引量：4
-
3类延娜,金海.脂联素与慢性心力衰竭相关性研究[J].中国心血管病研究,2009,7(8):626-628.
-
4杨西群,杜宇,邓茂,陈德宇.皮肌炎患者血清瘦素及白介素2和10水平的检测[J].临床皮肤科杂志,2008,37(1):24-25. 被引量：1
-
5刘超,武晓泓,蒋须勤.细胞凋亡与甲状腺[J].国外医学（内分泌学分册）,2000,20(2):69-73. 被引量：8
-
6李勤,王玉明,段勇.miRNAs与心血管疾病[J].现代检验医学杂志,2014,29(2):22-25. 被引量：6
-
7吴微,杨欢.MicroRNA与自身免疫性疾病[J].免疫学杂志,2010,26(12):1086-1090. 被引量：4
-
8潘宇,肖常青.瘦素与2型糖尿病及炎症[J].医学综述,2006,12(14):835-837. 被引量：3
-
9刘丽雅,洪振丰.表观遗传学与非酒精性脂肪肝病的研究进展[J].医学综述,2014,20(4):624-626.
-
10秧茂盛.细胞凋亡与动脉粥样硬化[J].中国动脉硬化杂志,1997,5(1):73-75. 被引量：4
