摘要
目的:研究血管扩张剂硝酸甘油联合阿司匹林治疗心绞痛的临床疗效。方法:选择我院2007年2月～2010年3月收治的90例心绞痛患者,随机分为两组,硝酸甘油联合阿司匹林治疗组(A组)45例和硝酸甘油治疗组(B组)45例,两组均给予硝酸甘油和复方丹参注射液或红花注射液静脉滴注。A组在B组的基础上加用阿司匹林,观察药物的治疗疗效和治疗前后心绞痛发作次数、血压、心率变化;并测定用药前后血糖、血脂、心肌酶的改善情况。结果:药物治疗后,A组总有效率为95.56%(43/45),B组总有效率为84.44%(38/45),两组差异有统计学意义(χ2=4.38,P<0.05);两组治疗后心电图进行比较,A组心电图有效率为97.78%(44/45),B组为82.22%(37/45),两组差异有统计学意义(χ2=8.25,P<0.05);63例(A组23例,B组40例)患者在服用硝酸甘油后出现头昏、头胀痛、低血压等症状,减少药物剂量后反应消失,未出现严重的副作用。结论:血管扩张剂联合治疗心绞痛能减缓耐药性发生,提高治愈率,值得在临床广泛应用。
Objective： To study clinical effect of vasodilator Nitroglycerin combined with Aspirin in treatment of angina pectoris.Methods： 90 patients with angina pectoris in our hospital from February 2007 to March 2010 were randomly divided into two groups,Nitroglycerin and Aspirin treatment group（group A） 45 cases and Nitroglycerin treatment group（group B） 45 cases.Patients in two groups were given Nitroglycerin with compound Danshen Injection or Safflower Intravenous Injection.Patients in group A were given Aspirin on basis of group B,therapeutic efficacy and angina pectoris,blood pressure,heart rate before and after treatment were observed,and blood glucose,blood lipids,enzymes before and after injection were measured.Results： After drug treatment,total effective rate of group A was 95.56%（43/45）,the total effective rate of group B was 84.44%（38/45）,the difference of two groups was statistically significant（χ2=4.38,P〈0.05）;ECG effective rate of group A was 97.78%（44/45）,that of group B was 82.22%（37/45）,the difference of two groups was statistically significant（χ2=8.25,P〈0.05）;63 cases of patients（23 cases in group A,40 cases in group B） had dizziness,head pain,hypotension and other symptoms after taking Nitroglycerin,response disappeared along with the dose reduced,there was no severe side effects.Conclusion： The combined treatment of angina pectoris can slow down the occurrence of drug resistance,improve cure rates,it should be widely used in clinical practice.
出处
《中国医药导报》
CAS
2011年第27期61-63,共3页
China Medical Herald
