摘要
非酒精性脂肪性肝病(NAFLD)事实上是一个肝脏脂肪性病变的疾病谱,包括单纯性脂肪肝、非酒精性脂肪性肝炎(NASH)、肝纤维化或肝硬化、肝衰竭,甚至部分患者发生肝细胞性肝癌。NAFLD与代谢综合征(MS)密切伴随,并认为是代谢综合征的肝脏表现。胰岛素抵抗可能是二者共同的发病基础。NAFLD已经成为MS、2型糖尿病(T2DM)和心血管疾病(CVD)的重要的独立预测因子,NAFLD成为T2DM和CVD高危人群,因此早期诊断和早期干预NAFLD对预防T2DM和CVD具有重要意义。
Nonalcoholic fatty liver disease （NAFLD） comprises a disease spectrum which includes variable degrees of simple steatosis nonalcoholic steatohepatitis （NASH） and cirrhosis even liver failure and patocellular carcinoma. NAFLD can be considered the hepatic manifestation of the metabolic syndrome and is an independent predictor of type 2 diabetes（T2DM） and cardiovascular disease （CVD）. Insulin resistance is the pathogenetic link between the metabolic syndrome and fat accumulation in the liver. Patients with NAFLD are a high risk population of the both of diseases. It＇s very important significance to early diagnosis and treatment of NAFLD for prevention T2DM and CVD.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2011年第9期664-667,共4页
Chinese Journal of Practical Internal Medicine
