双歧杆菌三联活菌胶囊对幽门螺杆菌感染消化性溃疡的治疗作用被引量：18

Therapeutic effect of Bifidobacterium triple viable capsule on peptic ulcer with helicobacter pylori infection

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摘要目的观察双歧杆菌三联活菌胶囊,对幽门螺杆菌感染消化性溃疡的治疗作用。方法筛选幽门螺杆菌感染的患者284例,随机分为两组;试验组使用双歧杆菌三联活菌胶囊+奥美拉唑肠溶片+阿莫西林胶囊+克拉霉素治疗,对照组只使用抗幽门螺杆菌三联治疗,测定治疗前及治疗后2、4周胃液pH值;治疗结束后统计患者出现的不良反应;治疗后4周观察溃疡及糜烂愈合情况及幽门螺杆菌的根除率。结果两组胃液pH治疗后均较治疗前升高,差异有统计学意义(P<0.05);治疗组不良反应发生率低于对照组;患者经治疗4周后复查胃镜,试验组与对照组溃疡的治愈率分别为75.6%和68.1%,差异无统计学意义;治疗组幽门螺杆菌根除率高于对照组,差异有统计学意义(P<0.05)。结论幽门螺杆菌感染消化道溃疡患者加用双歧杆菌三联活菌,能改善胃内pH值,减少不良反应,提高幽门螺杆菌的根除率,并促进糜烂愈合。 OBJECTIVE To observe the therapeutic effect of Bifidobacterium triple viable capsule on peptic ulcer with Helicobacter pylori（Hp） infection.METHODS A total of 284 patients with Hp infections were screened out and randomly divided into two groups.The use of the colon bacillus sanlian living bacterium capsule＋ ogilvy pull thiazole enteric-coated metformin hydrochloride ＋ amoxicillin capsule ＋ clarithromycin resistance to treatment group helicobacter pylori sanlian only using resistance to treatment,before and after treatment,the determination of treatment two weeks,four weeks pH value of gastric juice;after treatment with the adverse reactions occur statistics;Four weeks after treatment observation ulcer and erosion heal condition and Hp eradication rates.RESULTS Two groups of gastric juice which was treatment after treatment pH increased（P〈0.05）.The adverse reaction rate of treatment group was lower than that of the control group;four weeks after the patients＇ treatment,the cure rates of study group and control group review gastroscope,ulcer were 75.6% and 68.1%,respectively.Helicobacter pylori eradication rate in treatment group was higher than that in control group（P〈0.05）.CONCLUSION Helicobacter pylori infection with the peptic ulcer can be treated with Bifidobacterium triple viable capsule,which can improve the gastric aspirate pH value,reduce adverse reactions,improve helicobacter pylori eradication rates and promote the erosion healing.

作者汪明飞

机构地区贵州省合肥县人民医院内科

出处《中华医院感染学杂志》 CAS CSCD 北大核心 2011年第18期3943-3944,共2页 Chinese Journal of Nosocomiology

关键词双歧杆菌三联活菌胶囊幽门螺杆菌消化性溃疡治疗 Bifidobacterium triple viable capsule Helicobacter pylori Peptic ulcer Treatment

分类号 R978.1 [医药卫生—药品]

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