摘要
家兔113只,用钾离子透入法测痛,电针单侧“合谷”和“外关”穴,观察氯丙嗪、泰尔登、及异丙嗪对针刺镇痛的影响。实验发现,静注氯丙嗪0.1mg/kg、0.5mg/kg能降低痛阈,静注泰尔登0.025mg/kg、0.1mg/kg能提高痛阈,而2药均能显著降低针刺镇痛强度并缩短持续时间,呈量效关系。静注异丙嗪1mg/kg能降低痛阈,2mg/kg则提高痛阈,但2种剂量的异丙嗪均能减弱针刺镇痛。结果提示针麻临床应用加用上述药物应十分谨慎。
In 113 rabbits, the potassium iontophoretic dolorimetry was used for masurement of pain threshold The analgesic actions of chlorpromazine, chlorpro-thixene and promethazine and their effect on the electro-acupuncture analgesia (EAA)were studied. EAAwas carried out by unilateral 'Hegu' and 'Waiguan' points needling to which the electric pulsatile current was applied. Chlorpromazine(0.1 or 0.0 mg/kg iv)lowered the pain threshold, whereas chlorprothixene(0.025 or 0.1 mg/ kg iv)raised it.But these two drugs attenuated EAA in pain threshold and duration. Promethazine 1 mg/kg elicited a drop in pain threshold, while 2 mg/kg increased it. However, both dosages of promethazine attenuated EAA obviously. It is suggested that chlorpromazine, chlorprothixene and promethazine be avoided in clinical acupuncture anesthesia.
出处
《新药与临床》
CSCD
北大核心
1990年第6期325-327,共3页
关键词
针术
止痛
氯丙嗪
泰尔登
异丙嗪
acupuncture
analgesia
chlorpromazine
chlorprothixene
promethazine
