摘要
目的探讨茄病镰刀菌引起急性髓性白血病患者感染的诊断和治疗措施。方法对临床连续送检的脓液和坏死组织标本行真菌培养,根据真菌培养的菌落特点和镜下形态鉴定致病真菌,采用MIC方法进行真菌体外药敏试验。结果从造血干细胞移植术后患者全身出现的多发性皮下包块中采取标本,连续两次行真菌培养,均检测出茄病镰刀菌,体外药敏试验显示该菌对伏立康唑和两性霉素B有较低的MIC值,分别为2.0、4.0μg/ml。结论茄病镰刀菌对造血干细胞移植术后的感染少见,且难治疗,及时进行分离、培养、鉴定和药物敏感试验,正确选用抗菌药物、促进造血功能恢复,尤其是中性粒细胞、增强免疫功能,是治疗成功与否的关键。
OBJECTIVE To study the experimental diagnosis and treatment of infections with Fusarium solani in patient with leukemia.METHODS The successive pus and necrotic tissue were inoculated to mediums for fungi culture.RESULTS F.solani was isolated in the samples of the successive pus and skin secretions.F.solani was sensitive to the Voriconazole and the amphotericin B.CONCLUSION F.solani is a rare pathogen in the clinical infections which is difficult to cure.In cases of hypoimmunity,the multiple infections could be occured.Therefore,infection of Fusarium solani should be timely diagnosed and treated,the recovery of adequate neutrophil levels is the most important factor,so as to cure the disease rapidly and effciently.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第17期3614-3616,共3页
Chinese Journal of Nosocomiology
关键词
茄病镰刀菌
白血病
造血干细胞移植
Fusarium solani
Leukemia
Hematopoietic stem cell transplantation
