摘要
目的观察降血脂药HMG-CoA还原酶抑制剂阿托伐他汀钙对原发性高血压合并高胆固醇血症患者血压的影响。方法将56例血压控制良好的高血压合并高胆固醇血症的患者随机分为安慰剂组和阿托伐他汀钙组,半量治疗4周后能耐受者增加至目标剂量,随访8周。分别于研究开始、治疗12周时测定血压和血总胆固醇,低密度脂蛋白胆固醇、血三酰甘油等指标。结果治疗12周后安慰剂组和阿托伐他汀钙组的血压和血总胆固醇,低密度脂蛋白胆固醇指标间的差异均有统计学意义。结论阿托伐他汀钙在有效降低胆固醇的同时利于血压的控制。
Objective To observe the effect of Atorvastatin calcium on Blood pressure in patient with essential hypertension and hypercholesterolemia.Methods 56 patients with essential hypertension and hypercholesterolemia were randomly assigned to receive placebo,Atorvastatin calcium for 4 weeks,followed by titrating to the maximum recommended doses for another 8 weeks.The primary endpoint was the difference of mean sitting blood pressure and serum total cholesterol,low density lipoprotein cholesterol,triglycerides at baseline and week 12.Results At week 12,the difference between indexes of serum total cholesterol,low density lipoprotein cholesterol,and blood pressure in atorvastatin calcium and placebo group have statistically significant.Conclusion Atorvastatin calcium can lower blood pressure effectively without adverse effects on serum total cholesterol.
出处
《实用心脑肺血管病杂志》
2011年第10期1635-1636,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
