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DNA methylome and the complexity, of discovering prostate cancer biomarkers

DNA methylome and the complexity, of discovering prostate cancer biomarkers
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摘要 Prostate cancer （PCa） remains the most common malignancy and a leading cause of cancer-related ＇deaths in men. Molecular discrimination at an early stage between indolent and aggressive primary tumors in pathologically confirmed PCa is required to develop personalized therapeutic interventions. Prostate cancer （PCa） remains the most common malignancy and a leading cause of cancer-related ＇deaths in men. Molecular discrimination at an early stage between indolent and aggressive primary tumors in pathologically confirmed PCa is required to develop personalized therapeutic interventions.
作者 Shahriar Koochekpour
机构地区 Departments of Cancer Genetics and Urology
出处 《Asian Journal of Andrology》 SCIE CAS CSCD 2011年第5期661-662,共2页 亚洲男性学杂志（英文版）
分类号 Q78 [生物学—分子生物学] Q75 [生物学—分子生物学]
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参考文献8

  • 1Kobayashi Y, Absher DM, Gulzar ZG, Young SR, McKenney JK et al. DNA methylation profiling reveals novel biomarkers and important roles for DNA methyltransferases in prostate cancer. Genome Res; e-pub ahead of print 36 April 2011; doi: 10.1101/gr.119487.110.
  • 2Kron K, Pethe V, Briollais L, Sadikovic B, Ozcelik H et al. Discovery of novel hypermethylated genes in prostate cancer using genomic CpG island microarrays. PLoS One 2009; 4: e4830.
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  • 8Kwabi-Addo B, Wang S, Chung W, Jelinek J, Patierno SR et al. Identification of differentially methylated genes in normal prostate tissues from African American and Caucasian men. Clin Cancer Res 2010; 16: 3539-47.
Asian Journal of Andrology
2011年 第5期

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