摘要
目的观察吉西他滨联合替吉奥治疗晚期食管癌的疗效和毒副反应。方法 33例晚期食管癌均接受化疗:吉西他滨1 000mg/m2,d1,8,静脉滴注30 min;替吉奥80 mg/(m2.d),分2次口服,d1～14。每3周为1个周期,2个周期后评价疗效及毒副反应。结果 33例晚期食管癌中,CR 1例,PR 14例,SD 11例,PD 7例,总有效率为45.5%,临床获益率78.8%,中位疾病进展时间5.5个月。主要毒副反应为血液学毒性和消化道反应,且均可耐受。结论吉西他滨联合替吉奥治疗晚期食管癌疗效肯定,毒副反应可耐受。
Objective To observe the effect and toxicities of gemcitabine combined with S-1 in the treatment of patients with advanced esophageal cancer.Methods Thirty-three patients with advanced esophageal cancer received chemotherapy： gemcitabine 1 000 mg/m2,intravenous infusion for 30 min,d1,8;S-1 80 mg/（m2·d）,took orally,bid,d1-14,repeated every 3 weeks.The effect and toxicities were evaluated after 2 cycles.Results Of all the 33 patients,CR was observed in 1 case,PR in 14 cases,SD in 11 cases,PD in 7 cases,and the response rate was 45.5%,the clinical benefit rate was 78.8%,the median time to progression was 5.5 months.The main toxicities were hematological toxicities and digestive reactions,and they were tolerated.Conclusion Gemcitabine combined with S-1 is effect in the treatment of advanced esophageal cancer,and the toxicities can be tolerated.
出处
《肿瘤基础与临床》
2011年第4期293-295,共3页
journal of basic and clinical oncology
关键词
吉西他滨
替吉奥
晚期食管癌
gemcitabine
S-1
advanced esophageal cancer
