摘要
目的观察银杏达莫注射液对脑梗死患者血液流变学、血脂及血清C反应蛋白的影响。方法将62例脑梗死患者按照随机数字表法分为两组各31例，均给予常规治疗。对照组在常规治疗基础上给予复方丹参注射液20ml加入5％葡萄糖注射液250ml，静脉滴注，1次，d，连用14d。治疗组在常规治疗基础上给予银杏达莫注射液20ml加入5％葡萄糖注射液250ml，静脉滴注，1次／d，连用14d。观察治疗前后患者的临床症状、血液流变学指标、血脂水平及血清C．反应蛋白水平，并进行疗效评定。结果治疗组血液流变学指标以全血黏度降低最为明显（1．57±O．28）mpa·S（P〈0．01）。全血还原黏度（13．95±2．07）mpa·S、红细胞聚集指数（1．37±0．12）、红细胞压积（42．36±8．16）％亦下降，与对照组比较差异均有统计学意义（P〈0．05）。治疗组血清TG（1．23±0．12）mmol／L、TC（4．29±1．17）mmol／L、LDL．C（2．31±0．39）mmol／L较对照组明显降低（P〈0．01或P〈0．05）；血清HDL．C（I．78±0．76）mmol／L明显升高（P〈O．01）。治疗组血清C-反应蛋白（10．48±3．82）mg/L水平较对照组明显降低（P〈0．05）。治疗组总有效率为87．1％、对照组为67．7％，两组总有效率比较，差异有统计学意义（X^2=3．553，P=0．041〈0．05）。结论银杏达莫注射液可通过调整血液黏度、血脂水平改善脑梗死患者的症状。
Objective To observe effects of ginkgo bilobate extract injection on the hemorheology,blood lipid and c-reactive protein in serum of patients with cerebral infarction. Methods 62 cases patients with cerebral infarction were randomly divided into two groups by means of random number table. Two groups were both given routine treatment. The control group was treated with 20ml compound salvia injection, which was added to 250 ml normal saline, once a day, continuous therapy for 14 days, and the treatment group was treated with 20ml ginkgo bilobate extract injection, which was added to 250 ml normal saline, once a day, continuous therapy for 14 days. The clinical symptoms were observed, hemorheology related index, level of blood lipid and c-reactive protein were detected before and after the treatment. Results Compared with the control group, hemorheology related index decreased significantly in the treatment group, especially whole blood viscosity （ 1.57 ± 0.28 ） mpa ·s （P〈 0.01 ）. Blood reduced viscosity （ 13.95 ± 2.07 ） mpa ·s, erythroeyte aggregation index （ 1.37±0.12 ） , hematocrit （ 42.36± 8.16 ） were also decreased significantly （P〈 0.05 ） .Triglyceride （TG） （ 1.23± 0.12 ） mmol/L, cholesterol （ TC ） （ 4.29 ± 1.17 ） mmol/L, low density lipoprotein cholesterol （ LDL-C ） （2.31 ±0.39） mmol/L and c-reactive protein （10.48±3.82） mg/L in serum in the treatment group were lower than those of the control group （P〈0.01 or P〈0.05） , high density lipoprotein cholesterol （HDL-C） （ 1.78 ± 0.76） mmol/L in serum was higher than that of the control group （P〈0.01） .The total effective rate of the treatment group and the control group was 87.1% and 67.7% respectively, there was a significant difference （23= 3.553, P〈0.05） . Conclusion The ginkgo bilobate extract injection can protect cerebral infarction from injury, which may be related with its action on regulating the blood viscosity and level of blood lipid.
出处
《国际中医中药杂志》
2011年第9期783-785,共3页
International Journal of Traditional Chinese Medicine
关键词
脑梗死
银杏达莫注射液
复方丹参注射液
Cerebral infarction
Ginkgo bilobate extract injection
Edaravone injection
