摘要
目的:观察中药离子导入治疗弥漫性肺间质纤维化的的临床疗效。方法:随机双盲安慰剂对照设计,观察对象按照随机信封分为治疗组和对照组,对照组口服强的松1mg.kg-1.d-1,每经1个月治疗后减半量,三个月后以5mg/d维持量治疗,观察4个月。治疗组口服小剂量强的松;第1个月为每日10mg晨起顿服,第2个月减为5mg晨服,第3个月逐渐减量停服,在此基础上用紫草、红花、赤芍、丹参、皂刺等药物行中药离子导入,观察时间为4个月。两组同时给以相同的营养支持治疗药物,避免使用免疫抑制剂及中药活血化瘀制剂。结果:治疗组临床控制率、显效率及有效率明显高于对照组,无效率明显低于对照组,两组总体疗效有显著性差异(P<0.01)。在症状,肺功能等各项观测指标改善程度上治疗组也优于对照组(P<0.05)。结论:中药离子导入对弥漫性肺间质纤维化有很好的临床疗效。
Objective： To observe the clinical effect of treating diffuse interstitial pulmonary fibrosis with TCM iontophoresis. Methods： Randomized double-blind placebo-controlled design, observation objects were divide into treatment group and control group according to random envelope method, the control group taking prednisone 1mg·kg^-1·d^-1 for oral, half the amount every mouth, after 3 month, treated the disease with 5mg/d maintenance dose, observed for 4 months. The treatment group was given with low-dose prednisone; The first month, taking 10mg in the morning every day, the second month, reducing for 5mg in the morning, the third month gradually reducing to stop taking, on the bases, giving TCM iontophoresis with lithospermum, safflower, red peony, salvia, Zaoci and other medcines, the observation time for 4 month. The two groups were given the same nutrition support treatment medicine in the same time, avoided using immunosuppressive drugs and TCM Huoxue Huayu formulations. Result： The clinical control rate, markedly effective rate and effective rate of treatment group were higher than that of control group, the ineffective rate was lower than control group, the effect of two groups had significant difference （P〈0.01）. The degree of improvement of symptoms, lung function and other observations index in treatment group were better than that of control group （P〈0.05）. Conclusion： The clinical effect of treating diffuse interstitial pulmonary fibrosis with TCM iontophoresis.
出处
《中医临床研究》
2011年第16期3-4,共2页
Clinical Journal Of Chinese Medicine
