摘要
硫酸基转移酶(sulfotransferase,SULT)是机体催化多种内源性和外源性复合物硫酸化代谢的关键酶。人类SULT基因家族主要有:SULT1,SULT2,SULT4和SULT6,已确定的家族成员至少有13个。人体内能催化雌激素硫酸化的SULT主要包括SULT1E1,SULT1A1,SULT1A3和SULT2A1,其中SULT1E1对雌激素的亲和力最强,与雌激素的代谢密切相关。近年研究发现,子宫肌瘤、子宫内膜癌等妇科肿瘤中SULT1E1和SULT1A1表达异常,并发现SULT1E1和SULT1A1基因多态性与妇科肿瘤易感性相关。
Sulfonation is an important reaction in the metabolism of numerous exogenous and endogenous compounds. A supergene family of enzymes called sulfotransferases（SULTs）catalyze this reaction. In humans four SULT families,SULT1,SULT2,SULT4 and SULT6,have been identified that containning at least thirteen distinct members. Part of the SULT family members involved in metabolism of sex hormones sulfation. Research indicated abnormal SULT1A1 and SULT1E1 gene expression in uterine fibroids,endometrial cancer and other gynecological tumors and recent studies have begun to suggest roles of SULT1A1 and SULT1E1 polymorphism acting in gynecological tumors susceptibility.
出处
《国际妇产科学杂志》
CAS
2011年第4期324-327,共4页
Journal of International Obstetrics and Gynecology
