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宫颈癌发生过程中的表观遗传异常

Epigenetic Alterations in Cervical Carcinogenesis
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摘要 表观遗传指DNA序列不发生变化,而基因表达却发生可遗传的改变。在宫颈癌发生过程中,表观遗传改变不仅影响着人乳头瘤病毒(HPV)致癌基因的异常表达,而且可导致宿主细胞多个癌基因激活和抑癌基因的失活。近年发现,表观遗传和微小RNA(miRNA)相互调控异常也与宫颈癌发生密切相关。表观遗传异常可导致具有抑癌作用的miRNA沉默表达,miRNA也可通过DNA甲基化和组蛋白修饰促进病毒的DNA修复、抑癌基因表达沉默。 Epigenetics is defined as the study of inherited changes in phenotype or gene expression caused by mechanisms other than changes in the underlying DNA sequence. During cervical carcinogenesis, cancer-associated epigenetic alterations can affect the expression of HPV oncogenes. Additionally, it can control the overexpression of oncogene and underexpression of tumor-suppressor genes. Recent researches have proved that the abnormal interaction miRNAs and epigenetics definitively linked to HPV associated cervical cancer. Aberrant epigenetics are involved in silencing of tumor-suppressor miRNAs in carcinogenesis. On the other hand, miRNAs can improve the repair of viral DNA and silence tumor-suppressor genes by regulating DNA methylation or histone modifications.
作者 邢洁 李阳 吕卫国 谢幸
机构地区 浙江大学医学院附属妇产科医院
出处 《国际妇产科学杂志》 CAS 2011年第4期311-315,F0003,共6页 Journal of International Obstetrics and Gynecology
基金 国家自然科学基金(30973173 30872752)
关键词 后成说 遗传 微RNAS 宫颈肿瘤 乳头状瘤病毒科 Epigenesis genetic MicroRNAs Uterine cervical neoplasms Papillomaviridae
分类号 R737.33 [医药卫生—肿瘤]
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参考文献29

  • 1朱景德.组学时代的表观遗传学研究的机遇和挑战[J].中国科学基金,2009,23(4):196-202. 被引量：4
  • 2Berger SL. The complex language of chromatin regulation during transcription [J]. Nature, 2007, 447(7143): 407-412.
  • 3Bhattacharjee B, Sengupta S. CpG methylation of HPV 16 LCR at E2 binding site proximal to 1797 is associated with cervical cancer in presence of intact E2 [J]. Virology, 2006, 354(2): 280-285.
  • 4Palefsky J. Biology of HPV in HIV infection [J]. Adv Dent Res, 2006, 19(1): 99-105.
  • 5Burgers WA, Blanchon L, Pradhan S, et al. Viral oncoproteins target the DNA methyhransferases [J]. Oneogene, 2007, 26 (11 ): 1650- 1655.
  • 6Klose R J, Bird AP. Genomic DNA methylation: the mark and its mediators [J]. Trends Biochem Sci, 2006, 31 (2): 89-97.
  • 7Szalmas A, Konya J. Epigenetic alterations in cervical carcinogenesis [J]. Semin Cancer Biol, 2009, 19(3): 144-152.
  • 8Yang H J, Liu VW, Wang Y, et al. Differential DNA methylation profiles in gynecological cancers and correlation with clinico- pathological data [J]. BMC Cancer, 2006, 6: 212.
  • 9唐世倩,吴素慧.宫颈癌相关基因甲基化研究[J].临床医药实践,2009,18(3):163-165. 被引量：3
  • 10Henken FE, Wilting SM, Overmeer RM, et al. Sequential gene pro- moter methylation during HPV-induced cervical carcinogenesis [J]. BrJ Cancer, 2007, 97(10): 1457-1464.

二级参考文献16

  • 1Kang S, Kim J, Kim H B, et al. Methylation of p16INK4a is a non-rare event in cervical intraepithelial neoplasia [J]. Diagn Mol Pathol, 2006,15 ( 2 ) : 74- 82.
  • 2Kitkumthorn N, Yanatatsanajit P, Kiatpongsan S, et al. Cyclin A1 promoter hypermethylation in human papillomavirus-assoeiated cervical cancer [J]. BMC Cancer,2006,8(6):55.
  • 3Cheung T H,Lo K W,Yim S F,et al. Epigenetic and genetic alternation of PTEN in cervical neoplasm[J]. Gynecol Oncol, 2004,93 : 621-627.
  • 4Liu S S,Chan K N,Leung R U,et at. Enhancement of the radiosensitivity of cervical cancer cells by overexpressing p73alpha[J]. Mol Cancer Ther,2006, 5(5)..1 209-1 215.
  • 5Widschwendter A, Ivarsson L, Blassnig A ,et al. CDHI and CDH13 methylation in serum is an independent pmgnostic marker in cervical cancer patients [J]. Int J Cancer, 2004,109:163-166.
  • 6Zambrano P, Segura-Pachcco B. A phase Ⅰ study of hydralazine to demethylate and reactivate the expression of tumor suppressor genes [J]. BMC Cancer,2005(5):44.
  • 7Zhang Z, Huetmer P C, Nguyen L, et al. Aberrant promoter methylation and silencing of the POU2F3 gene in cervical cancer[J]. Oncogene, 2006,25(39): 5 436-5 445.
  • 8Lee T S, Kim J W, Kang G H, et al. DNA hypomethylation of CAGE promotors in squamous cell carcinoma of uterine cervix [J]. Ann N Yacad Sci, 2006,1091: 218-224.
  • 9Badal V,Chuang I. S,Tan E H,et al. CpG methylation of human papillomavirus type 16 DNA in cervical cancer cell lines and in clinical specimens: genomic hypomethylation correlates with carcinogenic progression[J]. J Virol,2003,77(11): 6 227-6 234.
  • 10Shuangshoti S,Hourpai N,Pumsuk U,et al. Line-1 hypomethylation in multistage carcinogenesis of the uterine cervix[J]. Asian Pac J Cancer Prey,2007,8 (2) :307-309.

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国际妇产科学杂志
2011年 第4期

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