法舒地尔对动脉瘤性蛛网膜下腔出血患者血浆ET-1水平的影响及作用机制探讨被引量：2

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摘要目的观察法舒地尔对动脉瘤性蛛网膜下腔出血(aSAH)患者血浆内皮素-1(ET-1)水平的影响,探讨其作用机制。方法 70例aSAH患者,随机分为观察组34例(常规治疗+法舒地尔)和对照组(常规治疗),各35例。两组均于发病后1、3、7、10、14 d采集静脉血。另选15例健康查体者为正常对照(正常组),查体时一次性采集。用放射免疫分析法测定血浆中ET-1,用经颅多普勒超声(TCD)检测大脑中动脉(MCA)的流速。结果观察组aSAH后1～10 d、对照组在aSAH后1～14 d时的血浆ET-1均高于正常组(P均<0.05),aSAH后14 d时观察组血浆ET-1水平与正常组相当(P>0.05),aSAH后1 d时的血浆ET-1水平观察组与对照组近似(P>0.05),3～14 d时观察组血浆ET-1水平明显低于对照组(P<0.05)。观察组aSAH后发生脑血管痉挛4例、对照组16例(P<0.05)。结论法舒地尔能降低aSAH患者血浆ET-1水平,这可能是其预防脑血管痉挛发生的机制之一。

作者张全忠任建军张信芳李文帅宋景元

机构地区菏泽市立医院

出处《山东医药》 CAS 北大核心 2011年第26期47-48,共2页 Shandong Medical Journal

关键词颅内动脉瘤蛛网膜下腔出血脑血管痉挛法舒地尔内皮素-1

分类号 R739.41 [医药卫生—肿瘤]

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参考文献11

1Vatter H, Konczalla J, Weidauer S, et al. Effect of delayed cerebral vasospasm on cerebrovascular endothelin A receptor expression and function[J]. J Neurosurg, 2007,107( 1 ) :121-127.
2张良文,吴承远,朱树干,刘玉光,江玉泉.颅内动脉瘤术后脑血管痉挛与血浆ET-1含量的相关研究[J].山东医药,2002,42(21):12-13. 被引量：4
3王寿先.盐酸法舒地尔对脑外伤后血浆内皮素变化的影响[J].第三军医大学学报,2008,30(15):1487-1488. 被引量：6
4施晓耕.TCD诊断蛛网膜下腔出血迟发脑血管痉挛的新进展[J].国外医学（内科学分册）,1998,25(1):25-27. 被引量：15
5Harrod CC, Bendok BR, Batjer HH. Prediction of cerebral vasospasm in patients presenting with aneurysmal subaraehnoid hemorrhage: a review[J]. Neurosurgery, 2005, 56(4) :633-654.
6Kessler IM, Pacheco YG, Lozzi SP, et al. Endothelin-1 levels in plasma and cerebrospinal fluid of patients with cerebral vasospasm after aneurysmal subarachnoid hemorrhage [ J ]. Surg Neurol, 2005,64 (Suppl):2-5.
7Xie A, Aihara Y, Bouryi VA, et al. Novel mechanism of endothelin-1 nduced vasospasm after subarachnoid hemorrhage [ J ]. J Cereb Blood Flow Metab, 2007,27 (10) :1692-1701.
8Suzuki Y, Shibuya M, Satoh S, et al. A postmarketing suveillance study of fasudil treatment after aneurismal subarachnoid hemorrhage [J]. Surg Neurol, 2007,68(2) :126-131.
9陈勇军,张新华,邹伟,刘淑云,蒋福生.盐酸法舒地尔对蛛网膜下隙出血后血浆和脑脊液中内皮素-1和一氧化氮水平的影响。[J].中国医师进修杂志,2010,33(1):22-24. 被引量：4
10Wang YX, Martin-McNulty B, da-Cunha V, et al. Fasudil, a Rhokinase inhibitor, attenuates angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice by inhibiting apoptosis and proteolysis [ J ]. Circulation, 2005,111 (17) :2219-2226.

二级参考文献13

1Kobayashi H,Hayashi M,Kobayshi S,et al.Effect of endothelin on the canine basilar artery.Neurosurgery,1990,127:357～361.
2Masaoka H,Suzuki R,Hirata Y,et al.Raised plasma endothelin in aneurysmal subarachnoid hemorrhage.Lancet,1989,2:1402.
3Fujimori A,Yansgisawa M,Saito A,et al.Endothelin in plasma and cerebrospinal fluid of patients with subarachnoid haemorrhage.Lancet,1990,336:633.
4Ziv I,Fleminger G,Djaldetti R,et al.Increased plasma endothelin-1 in acute ischemic stroke.Stroke,1992,23:1014～1016.
5Coimbra C ,Wieloch T. Moderate hypothermia mitigates neuronal damage in the rat brain when initiated several hours following transient cerebral ischemia[J]. Acta Neuropathol, 1994, 87(4) : 325 -331.
6Wang Y X, Martin-McNuhy B, da-Cunha V, et al. Fasudil, a Rho-kinase inhibitor, attenuates angiotensin Ⅱ-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice by inhibiting apoptosis and proteolysis[J] . Circulation, 2005, 111 (17) : 2219 - 2226.
7Nakamura K, Nishimura J, Hirano K, et al. Hydroxyfasudil, an active metabolite of fasudil hydrochloride, relaxes the rabbit basilar artery by disinhibition of myosin light chain phosphatase[ J]. J Cereb Blood Flow Metab, 2001, 21(7): 876-885.
8Rikitake Y, Kim Y Y, Huang Z, et al. Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection [J]. Stroke, 2005, 36(10): 2251 - 2257.
9C. Schaller,V. Rohde,B. Meyer,W. Hassler. Amount of subarachnoid blood and vasospasm: Current aspects[J] 1995,Acta Neurochirurgica(1-2):67～71
10D. G. Grosset,I. McDonald,M. Cockburn,J. Straiton,R. R. Bullock. Prediction of delayed neurological deficit after subarachnoid haemorrhage: a CT blood load and Doppler velocity approach[J] 1994,Neuroradiology(6):418～421