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ZEB家族与肿瘤 被引量：6

ZEB family and tumor
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摘要 锌指结构转录因子中的E盒结合锌指蛋白(zinc finger E-box-binding protein,ZEB)家族是胚胎发育中必须的转录因子,ZEB基因的突变能够引起严重的畸形,同时ZEB能通过调节细胞周期、凋亡、衰老、侵袭转移和间质血管生成等方面调节恶性肿瘤进展,本文将概述ZEB家族与恶性肿瘤发展间的关系。 The zinc finger E-box-binding protein（ZEB） family of zinc finger transcription factor is an essential player during normal embryonic development.Mutations in ZEB encoding genes cause severe syndromic malformations.Recent studies have shown that the ZEB can regulate tumor progression by regulating cell cycle progression,apoptosis,senescence,angiogenesis,invasion and metastasis.In this review,we summarized the relationship between ZEB family and the progression of cancer.
作者 毛苡泽 王世宣
机构地区 华中科技大学同济医学院第二临床学院妇产科 华中科技大学同济医学院附属同济医院妇产科
出处 《国际病理科学与临床杂志》 CAS 2011年第4期333-337,共5页 Journal of International Pathology and Clinical Medicine
关键词 ZEB1 ZEB2/SIP1 肿瘤 zinc finger E-box-binding protein 1 zinc finger E-box-binding protein 2/Smad interacting protein 1 tumor
分类号 R730.2 [医药卫生—肿瘤]
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参考文献37

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同被引文献59

  • 1王继恒,李世荣.我国结直肠癌筛查和早期诊断十年回顾:1994～2005[J].胃肠病学,2006,11(4):245-250. 被引量：51
  • 2Liu Z, Sun B, Qi L, et al. Zinc finger E-box binding homeobox 1 promotes vasculogenic mimicry in colorectal cancer through induction of epithelial-to-mesenchymal transition. Cancer Sci, 2012, 103(4): 813-820.
  • 3Swisshelm K, Macek R, Kubbies M. Role of elaudins in tumorigenesis. Adv Drug Deliv Rev, 2005,57 (6) : 919-928.
  • 4Kinugasa T, Huo Q, Higashi D, et al. Selective up-regulation of claudin-1 and claudin-2 in colorectal cancer. Anticancer Res, 2007,27 (6A): 3729-3734.
  • 5Dhawan P, Singh AB, Deane NG, et al. Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer. J Clin Invest, 2005,115 (7):1765-1776.
  • 6Shen A, Zhang Y, Yang H, et al. Overexpression of ZEB1 relates to metastasis and invasion in osteosarco- ma. J Surg Oncol,2011,105(8):830-834.
  • 7Jia B, Liu H, Kong Q, et al. Overexpression of ZEB1 associated with metastasis and invasion in patients with gastric carcinoma. Mol Cell Biochem,2012,366(1):223- 229.
  • 8Montserrat N, Gallardo A, Escuin D, et al. Repression of E-cadherin by SNAIL, ZEB1, and TWIST in invasive ductal carcinomas of the breast: a cooperative effort. Hum Pathol,2011,42(1) :103-110.
  • 9Spaderna S, Schmalhofer O, Wahlbuhl M, et al. The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer. Cancer Res,2008,68 (2) :537-544.
  • 10Liu Y, Yah X, Liu N, et al. Lentivirus-delivered ZEB-1 small interfering RNA inhibits lung adenocarcinoma cell growth in vitro and in vivo. J Cancer Res Clin Oncol, 2012,138(8) : 1329-1338.

引证文献6

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国际病理科学与临床杂志
2011年 第4期

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