摘要
巨噬细胞是机体免疫系统的重要细胞成份,具有多种生理功能,在动脉粥样硬化等血管疾病的发生和发展中具有重要作用。巨噬细胞凋亡是造成动脉粥样硬化斑块不稳定的重要因素,在晚期动脉粥样硬化中,内质网应激与巨噬细胞凋亡密切相关。目前已知的巨噬细胞凋亡途径包括外源性的死亡受体途径、内源性的线粒体途径及内质网应激凋亡途径,其中内质网应激途径是新近发现的凋亡途径,其作用机制仍有待研究。
Macrophages are important cell component of the immune system with multiple functions and play crucial roles in the development of atherosclerosis and other vascular diseases.Macrophage apoptosis is a key factor leading to instability of atherosclerotic plaques.In the late stage of atherosclerosis,macrophage apoptosis is closely related to endoplasmic reticulum（ER） stress.Macrophage apoptosis is mediated by two central pathways： the extrinsic（or death receptor） pathway and the intrinsic（or mitochondrial,endoplasmic reticulum stress） pathway.The later has been found for a few years but the mechanisms still remain poorly understood.
出处
《国际病理科学与临床杂志》
CAS
2011年第4期315-318,共4页
Journal of International Pathology and Clinical Medicine
关键词
巨噬细胞
凋亡
内质网应激
动脉粥样硬化
macrophage
apoptosis
endoplasmic reticulum stress
atherosclerosis
