摘要
探讨血清抗氧化应激指标超氧化物歧化酶(SOD)在不同期别矽肺患者和矽肺合并感染的患者中的变化,为煤工尘肺早期损伤的监测和防治提供可能的线索。选取矽肺病人210例,其中I期94例,Ⅱ期95例,Ⅲ期21例。分组后检测血清超氧化物歧化酶(SOD)的水平。结果显示:矽肺组及矽肺合并其它疾病组血清SOD水平均较对照组明显降低,差异具有统计学意义(P<0.05);在矽肺合并其它疾病的组别中,以矽肺合并结核和其他呼吸道疾病组SOD水平降低最为明显,差异具有统计学意义(P<0.05);在不同期别矽肺合并结核的患者血清中,SOD水平亦有明显降低,且随矽肺的进展增加SOD下降幅度加大。超氧化物歧化酶(SOD)的检测有可能作为煤工尘肺病人早期损伤监测的辅助指标,在煤工尘肺病人中抗氧化治疗对延缓或抑制矽肺病变的发展具有一定的临床应用价值。
To explore the changes of an antioxidant index superoxide dismutase（SOD） in patients at various stages of silicosis and silicosis patients with infection to provide possible documents for monitoring the early injury in silicosis of coal workers,210 cases of silicosis patients of which 94 cases in stage I,95 cases in stage II and 21 cases in stage III were selected.The patients were grouped according to the disease development.The serum SOD levels in patients were measured.The results showed that the serum SOD levels in silicosis patients and silicosis patients with other disease were significantly lower than that of controls（P0.05）.The serum SOD levels in silicosis patients with tuberculosis and other respiratory disease group decreased significantly.The serum SOD levels were decreased in each stage of silicosis patients,and the decline of SOD levels was correlated with the progression of disease.Superoxide dismutase may be used as an indicator for early damage monitoring of coal workers pneumoconiosis.The detection of superoxide dismutase has clinical values in antioxidant therapy and inhibiting the development of silicosis for coal workers pneumoconiosis.
出处
《标记免疫分析与临床》
CAS
2011年第4期219-221,共3页
Labeled Immunoassays and Clinical Medicine
关键词
矽肺
超氧化物歧化酶
Silicosis
Superoxide dismutase
