摘要
目的检测基质金属蛋白酶-2（MMP-2）、半胱氨酸富集蛋白61（Cyr61）及CD25在食管鳞癌中的表达并探讨其临床意义。方法采用免疫组织化学法分别检测68例食管鳞癌患者肿瘤组织（食管癌组）、癌旁组织（癌旁组）和68例反流性食管炎患者病变组织（对照组）中的MMP-2、Cyr61及CD25对检测结果进行统计分析。结果食管癌组中MMP-2、Cyr61和CD25的阳性表达率分别为82．35％（56／68）、73．53％（50／68）和89．71％（61／68），与癌旁组、对照组比较差异均有统计学意义（P〈0．05）；癌旁组与对照组比较差异无统计学意义（P〉0．05）；食管癌组织中MMP-2、Cyr61和CD25的阳性表达率在不同T分期、N分期和M分期中差异均有统计学意义（P〈0．05），在不同的分化程度中差异则无统计学意义（P〉0．05）。结论MMP-2、Cyr61及CD25在食管鳞癌中均有高表达，对其进行检测对了解食管鳞癌的发生、发展以及预后判断有一定指导意义。
Objective To determine the expression of matrix metalloproteinase-2 （MMP-2）, cysteine rich protein 61 （Cyr61） and CD25 in esophageal carcinoma and investigate their clinical significance. Method The expression of MMP-2,Cyr61 and CD25 in 68 cases of esophageal tumor tissues （esophageal carcinoma group） and para-cancer（para-cancer group） and 68 cases of reflux esophagitis（control group） was detected by immunohistochemical method and the results were statistically analysed. Results The positive expression rates of MMP-2,Cyr61 and CD25 were 82.35% （56/68）, 73.53% （50/68） and 89.71% （61/68） respectively in esophageal carcinoma group,there were significant differences compared with those in paracancer group and control group（P 〈 0.05 ） ;while there was no significant difference between para-eancer group and control group （P 〉 0.05 ）. The positive expression rates of MMP-2, Cyr61 and CD25 in esophageal carcinoma group in different T stage, N stage and M stage all had statisticall differences （P 〈 O.05）,while there was no significant difference in different degree of differentiation （P 〉 0.05 ）. Conclusion MMP-2, Cyr61 and CD25 is highly expressed in esophageal carcinoma,there is some significance for understanding the occurrence, development and prognosis of esophageal carcinoma.
出处
《中国医师进修杂志》
2011年第24期27-29,共3页
Chinese Journal of Postgraduates of Medicine
