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微小RNA与骨髓增生异常综合征的研究进展 被引量：1

Advance of Studies on MicroRNA and Myleodysplastic Syndrome——Review
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摘要 微小RNA(microRNA,miRNA)是内源性、非编码的长度约22个核苷酸的单链RNA分子,在多种物种间高度保守。miRNA分子参与体内众多生理、病理过程,如发育、分化、凋亡、细胞增殖和肿瘤发生。骨髓增生异常综合征(myelodysplastic syndrom,MDS)是起源于造血干细胞的异质性克隆性疾病,以无效的病态造血和高风险向白血病转化为特征。本文就miRNA分子在MDS发病及预后中扮演的角色做一综述,讨论的问题包括:与MDS发病相关的miRNA,与MDS预后相关的miRNA等。 MicroRNA （ miRNA）, evolutionarily conserved, endogenous, small, noncoding RNA molecule of about 22 nucleotides in length, have been recently attributed a crucial role in numerous physiological and pathological processes including the regulation of cellular development, differentiation, proliferation, apoptosis and oncogenesis. Myelodysplastic syndrome （MDS） is a heterogeneous group of clonal hematologic disorders characterized clinically and morphologically by ineffective hematopoiesis and increased risk of leukaemic transformation. The role of miRNA abnormal expression in pathogenesis and prognosis of MDS is reviewd in this article, including miRNA related with pathogeuesis, miRNA related with prognosis of MDS and so on.
作者 杨宇娟 李晓
机构地区 上海交通大学附属市第六人民医院血液科
出处 《中国实验血液学杂志》 CAS CSCD 2011年第4期1079-1082,共4页 Journal of Experimental Hematology
关键词 骨髓增生异常综合征 MIRNA 无效造血 myleodysplastic sydrome microRNA ineffective hematopoiesis
分类号 B733.3 [哲学宗教—外国哲学] R733.7 [医药卫生—肿瘤]
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参考文献27

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同被引文献35

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引证文献1

中国实验血液学杂志
2011年 第4期

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