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杂合式肾脏替代与持续床旁血液滤过在移植肾功能延迟的应用比较

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摘要 目的对比观察间断透析滤过的杂合式肾脏替代(HRRT)治疗和持续床旁血液滤过(CRRT)对肾移植术后肾功能延迟恢复(DGF)患者炎症介质的影响,并初步评定两者的临床效果。方法术后发生DGF的肾移植患者25例,采用日间间断透析滤过的HRRT治疗15例,采用CRRT治疗10例,治疗前后测定其肾功能和补体C3、C4和C反应蛋白水平,并应用ELISA方法测定IL-1β、IL-6和TNF-α水平。结果 25例患者移植肾功能于1个月左右恢复。两种方法治疗后Scr、BUN均明显下降(P<0.01),IL-1β和IL-6和TNF-α明显降低(P<0.05),补体和C反应蛋白水平有所降低但差异无统计学意义(P>0.05)。HRRT与CRRT治疗相比,治疗时间短,肾脏恢复时间相近。结论日间间断透析滤过的HRRT治疗可降低患者体内部分细胞因子水平,与CRRT相比治疗时间短,肾功能恢复时间相当,可作为DGF患者过渡期肾脏替代治疗。
作者 蔡文利 苗书斋 王沛育 曲青山
机构地区 河南省郑州人民医院器官移植科
出处 《广东医学》 CAS CSCD 北大核心 2011年第16期2188-2190,共3页 Guangdong Medical Journal
关键词 肾功能延迟恢复 肾移植 杂合式肾脏替代 细胞因子 持续床旁肾脏替代治疗
分类号 R699.2 [医药卫生—泌尿科学]
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参考文献15

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广东医学
2011年 第16期

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