摘要
目的探讨IgA肾病患者尿白介素-6(尿IL-6)水平与肾小管间质损伤的相关性。方法采用酶联免疫吸附法(ELISA)检测50例IgA肾病患者及40例健康对照者尿IL-6水平,并对IgA肾病组肾小管间质病理损伤进行半定量评分。结果 IgA肾病组尿IL-6水平明显高于健康对照组(P<0.01);IgA肾病患者尿IL-6水平与尿NAG酶/尿Cr呈正相关(r=0.45,P<0.01),并与肾脏病理中的肾间质炎症细胞浸润指数(r=0.28,P<0.05)、肾小管萎缩和肾间质纤维化指数(r=0.41,P<0.01)均呈正相关,还与IgA肾病肾小管间质损伤程度分级呈良好等级相关性。结论尿IL-6水平可以间接反映IgA肾病患者肾小管间质尤其是近端小管的损伤程度。
Objective To observe the correlation between urinary IL-6 and tubulointerstitial injury in IgA nephropathy. Methods Used the ELISA to test the urinary IL-6 levels of 50 cases with IgA nephropathy and 40 healthy controls, while tested semi-quantitative score of IgA nephropathy tubulointerstitial pathological damage. Results The urinary IL-6 of IgA nephropathy were obviously higher than that in the healthy control group （P〈0.01）. There was a positive correlation （r=0.45, P〈0.01） between the urinary IL-6 levels of IgA nephropathy and urinary NAG enzyme/urine Cr, so was the renal pathology in renal interstitial inflammatory cell infiltration index （r=0.2g, P〈 0.05）, tubular atrophy and interstitial fibrosis index （r=0.41, P〈0.01）. Moreover, urinary IL-6 levels had correlation with tubulointerstitial injury in IgA nephropathy. Conclusion IL-6 levels in patients with IgA nephropathy can indi- rectly reflect tubulointerstitial lesions, especially the proximal tubules injury degree.
出处
《海南医学》
CAS
2011年第17期1-3,共3页
Hainan Medical Journal
基金
2009年度海南省自然科学基金课题(编号:309095)
