摘要
目的检测急性冠脉综合征(ACS)患者外周血淋巴细胞亚群及T淋巴细胞活性并探讨其临床意义。方法 290例ACS患者,其中不稳定型心绞痛(USAP)111例,非ST段抬高心肌梗死(NSTEMI)88例,ST段抬高心肌梗死(STEMI)91例。取外周静脉血2mL,采用流式细胞仪分析淋巴细胞亚群变化及T淋巴细胞活化情况,并与100例稳定型心绞痛(SAP)患者对照。结果与SAP组比较,USAP、NSTEMI及STEMI组Th细胞百分比及Th/Ts细胞比值均升高(P<0.05),Ts细胞百分比降低(P<0.05),Th细胞激活百分比显著升高(P<0.001)。结论 ACS患者免疫调节功能异常,T淋巴细胞激活,这可能是导致冠脉粥样硬化斑块不稳定的原因之一。
Objective To investigate changes of lymphocyte subgroup and T lymphocyte activation in patients with acute coronary syndrome（ACS） and its clinical significance.Methods Lymphocyte subgroup and T lymphocyte activation percentage were detected in 290 ACS patients,and were compared with 100 patients with stable angina pectoris（SAP）.Results Comparing with SAP group,Th percentage and the ratio of Th/Ts were higher（P0.05 or 0.01）,Ts percentage were lower in ACS patients（P0.05）.The activated Th lymphocyte were significantly higher in ACS patients（P0.01）.Conclusion T lymphocyte activated and the immunomodulation function were disturbed in ACS patients and this may contribute to the instability of the plaque.
出处
《贵州医药》
CAS
2011年第7期591-592,共2页
Guizhou Medical Journal
