摘要
目的:观察异甘草酸镁注射液对化疗药物所致急性肝损伤的防治作用。方法:第1周期化疗后出现Ⅱ°药物性肝损伤且经保肝治疗后恢复正常的恶性肿瘤患者94例,在进行第2周期化疗的同时,应用异甘草酸镁注射液150mg(治疗组,47例)或还原型谷胱甘肽注射液1.2g(对照组,47例)进行预防性保肝治疗,均为1次/d,疗程2周。肝损伤<Ⅱ°者为有效。结果:治疗后治疗组与对照组的有效率分别为80.9%、55.3%(P<0.01),丙氨酸氨基转移酶分别为(20.8±9.4)、(35.4±7.1)U·L-(1P<0.05)。结论:异甘草酸镁注射液对于化疗药物所致急性肝损伤有良好的防治作用。
OBJECTIVE： To observe the effects of Magnesium isoglycyrrhizinate injection preventing acute liver damage induced by chemotherapy drugs. METHODS： 94 patients with malignant tumor suffered from Ⅱ degree drug-induced liver injury after first chemotherapy cycle then were cured after liver protection treatment. Treatment group was treated with Magnesium isoglycyrrhizinate injection 150 mg （47 cases） and control group was treated with Reduced glutathione injection 1.2 g （47 cases） once a day for 2 weeks during the second chemotherapy cycle. The treatment which was lower than Ⅱ degree drug-induced liver injury was effective. RESULTS： After treatment, the effective rates were 80.9% for treatment group and 55.3% for control group （P〈0.01）, and the contents of ALT were （20.8 ± 9.4）U·L^-1 and （35.4 ±7.1）U·L^-1 respectively （P〈0.05）. CONCLUSION： Magnesium isoglycyrrhizinate injection can prevent acute liver injury induced by chemotherapy drugs effectively.
出处
《中国药房》
CAS
CSCD
北大核心
2011年第34期3218-3220,共3页
China Pharmacy
关键词
异甘草酸镁
化疗药物
急性肝损伤
预防性
保肝治疗
Magnesium isoglycyrrhizinate
Chemotherapy drugs
Acute liver injury
Preventive
Liver protection treatment
