摘要
目的初步探讨聚乙二醇干扰素α-2a治疗慢性乙型肝炎患者T淋巴细胞和mDCs上共刺激分子B7-H1/PD-1表达与早期病毒学应答的关系。方法纵向观察接受聚乙二醇干扰素α-2a治疗的28例CHB患者其mDCs和T细胞上B7-H1/PD-1的表达变化,分析B7-H1/PD-1表达与聚乙二醇干扰素α-2a治疗效果之间的关系。结果聚乙二醇干扰素α-2a治疗12周时,早期病毒学应答组患者B7-H1在CD3+T细胞、CD4+T细胞、CD8+T细胞、mDC上表达及PD-1在CD3+T细胞、CD4+T细胞、CD8+T细胞上表达水平均明显低于非早期病毒学应答组患者,两组差异显著,P值分别为0.009,0.009,0.009,0.042,0.004,0.017,0.004。结论聚乙二醇干扰素α-2a抗病毒疗效可能与CHB患者mDCs和T细胞上B7-H1/PD-1的表达相关。
Objective To discuss the relationship between remedying T lymphocytes mDCs and costimulatory molecule of B7-H1/PD-1 expression of chronic hepatitis B with pegylated interferon α-2a and early virological response.Methods Observing expression changes of T lymphocytes mDCs and costimulatory molecule of B7-H1/PD-1 of 28 patients with CHB receiving pegylated interferon α-2a treatment.Analyze the relationship between B7-H1/PD-1 expression and pegylated interferon α-2a treatment effect.Results The expression level of B7-H1 in CD3＋T cells,CD4＋T cells,CD8＋T cells,mDC and PD-1 in CD3＋T cells,CD4＋T cells,CD8＋T cells of early virological response patients were significantly lower than non-early virologic response patients.There were significant differences between the two groups.P values were 0.009,0.009,0.009,0.042,0.004,0.017,0.004.Conclusion Antiviral efficacy of pegylated interferon α-2a may be related to the expression of B7-H1/PD-1 in mDCs and T cells of CHB patients.
出处
《中国病案》
2011年第8期63-65,共3页
Chinese Medical Record
