期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

抗倒酯的合成研究 被引量：1

Study on synthesis of trinexapac-ethyl
原文传递
导出
摘要 以丙酮和马来酸二乙酯为原料,经过迈克尔加成、环合、酰化及重排反应合成了抗倒酯,4步反应总收率63.4%。中间体及产品经~1HNMR和质谱表征。该方法具有操作简单、成本低、收率高等优点,适合工业化生产。 Trinexapac-ethyl was synthesized by using acetone and diethyl maleate as the starting material via Michael addition,cyclization,acylation and rearrangement.The total yield of four steps was 63.4%.Structure of the product and intermediate was confirmed by ~1HNMR and MS.This method has many advantages,such as easy operation,low cost and high yield,which can be feasible to large scale preparation.
作者 朱长松 黄斌 刘骏结 阳军 吉建飞 王明亮
机构地区 东南大学成贤学院化工与制药工程系 东南大学化学化工学院
出处 《精细与专用化学品》 CAS 2011年第8期11-13,共3页 Fine and Specialty Chemicals
基金 2010年江苏省高等学校大学生实践创新训练计划立项项目(苏教高[2010]27号 编号60)
关键词 马来酸二乙酯 迈克尔加成 环合 酰化 重排 抗倒酯 diethyl maleate Michael addition cyclization acylation rearrangement trinexapac-ethyl
分类号 TQ452.1 [化学工程—农药化工]
  • 相关文献

参考文献6

  • 1Motojima K, Miyazawa T, Toyokawa Y, et al. Cyclohexane derivatives having plant-growth regulating activities, and uses of these derivatives[P]. EP123001, 1984-10-31.
  • 2高敏,王晓钟,戴立言,陈英奇.抗倒酯的合成工艺[J].农药,2006,45(8):535-536. 被引量：5
  • 3Jian-Lin Huang, Hun-Ge Liu, Ding-Yah Yang. Acylcyclohexanedione derivatives as potential in vivo sequential inhibitors of 4 hydroxyphenylpyruvate dioxygenase and GA20 3-hydroxylase [J]. Bioorganic & Medicinal Chemistry Letters, 2003, (13) : 927-930.
  • 4Brunner H G. Preparation of cyclohexanedionecarboxylic acid derivatives as herbicides and plant growth regulators [P]. US4693745, 1983-12-19.
  • 5Jaouhari R, Maillnad B, FilliatreC, etal. A free-radical acetonylation method [J].Snythesis, 1982, 9:760 -763.
  • 6Kokai J, Tokkyo K. Methyl and ethyl acetonylsuccinates [P]. JP59163346, 1984-9-14.

二级参考文献10

  • 1Motojima K,Miyazawa T,Toyokawa Y,et al.Cyclohexane derivativeshaving plant-growth regulating activities,and uses of these derivatives:EP,123001[P].1984-10-31.
  • 2Brunner H G.Preparation of cyclohexanedionecarboxylic acid derivatives as herbicides and plant growth regulators:US,4693745[P].1983-10-18.
  • 3Kuehne M E,Lambert B F.The reduction of aromatic acids and amides by sodium in liquid ammonia[J].J Am Chem Soc,1959,81:4278-4287.
  • 4Fran K,George W,Holland J L.Use of a carboxy-inversion reacion[J].J Org Chem,1973,38(19):3440-3442.
  • 5Motojima K,Miyazawa T,Toyokawa Y,et al.Cyclohexane derivatives having plant-growth regulating activities,and uses of these derivatives:EP,123001[P].1984-10-31.
  • 6Kokai J,Tokkyo K.Methyl and ethyl acetonylsuccinates:JP,59163346[P].1984-09-14.
  • 7Wu B G,Bai D L.The first total synthesis of(±)-huperzine B[J].J Org Chem,1997,62(17):5978-5981.
  • 8Huang Jianlin,Liu Hun'ge,Yang Dingyah.Acylcyclohexanedione derivatives as potential in vivo sequential inhibitors of 4-hydroxyphenylpyruvate dioxygenase and GA20 3β-hydroxylase[J].Bioorganic & Medicinal Chemistry Letters,2003,13(5):927-930.
  • 9Eugene E T,George T H.The synthesis of tropone and tropolone via a norcarenone→cycloheptadienone rearrangement[J].J Am Chem Soc,1956,78:4405-4412.
  • 10吴迎晓,戴立言.中间体O-3-氯-2-丙烯基羟胺的制备[J].农药,2004,43(3):113-114. 被引量：7

共引文献4

同被引文献7

引证文献1

精细与专用化学品
2011年 第8期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部