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Reg基因蛋白家族的研究进展 被引量：3

Advances in regenerating gene protein family
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摘要 Reg基因蛋白(regenerating gene protein)属于钙依赖的植物血凝素超家族,其功能类似应激蛋白、抗凋亡因子或生长因子。Reg基因蛋白的促进胰岛β细胞分裂和诱导再生作用最早是在糖尿病研究中被发现。Reg基因蛋白在人体多种组织中均表达,与细胞增殖、炎症创伤、感染和神经系统发育关系密切。随着研究的深入,Reg基因蛋白在胰腺损伤修复、神经系统损伤、消化系统肿瘤、脓毒血症及其他疾病中的作用逐渐引起人们重视。 Regenerating gene proteins（Reg） belong to the calcium-dependent lectin gene superfamily,which act as stress proteins,anti-apoptotic factors,and growth factors.It can induce islet β cell proliferation and promote regeneration,which were initially revealed in the study of diabetes.Reg are expressed in various tissues and involved in cellular proliferation,inflammation,infection and neural development.In recent years,the new role of reg in pancreatic repair,neuronal regeneration,gastrointestinal cancers,and sepsis has spawned significant scientific interests.
作者 刘凤 孙子林 陈平圣 李玲
机构地区 东南大学医学院病理教研室 东南大学附属中大医院内分泌科
出处 《生命科学》 CSCD 北大核心 2011年第8期767-772,共6页 Chinese Bulletin of Life Sciences
基金 国家自然科学基金项目(30900696) 江苏省自然科学基金项目(BK2009278)
关键词 Reg基因蛋白 胰腺炎 糖尿病 肿瘤 regenerating gene protein pancreatitis diabetes tumor
分类号 Q754 [生物学—分子生物学] R394 [医药卫生—医学遗传学]
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参考文献47

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  • 4Watanabe T, Yonekura H, Terazono K, et al. Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. J Biol Chem, 1990, 265(13): 7432-9.
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二级参考文献36

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共引文献3

同被引文献35

  • 1刘海波,曹雪涛.C型凝集素受体CLR与负性免疫调节[J].现代免疫学,2005,25(4):344-346. 被引量：2
  • 2万永奇,谢维.生命科学与人类疾病研究的重要模型——果蝇[J].生命科学,2006,18(5):425-429. 被引量：58
  • 3温振科,熊思东（审校）.C型凝集素受体对固有免疫应答的双向调节作用[J].国际免疫学杂志,2007,30(3):178-180. 被引量：2
  • 4Ao J, Ling E, Yu XQ. Drosophila C-type lectins enhance cellular encapsulation[J]. Mol Immunol, 2007, 44(10) : 2541 -2548.
  • 5Fukuhara H, Furukawa A, Maenaka K. New binding face of C-type lectin-like domains[J]. Structure, 2014, 22(12) : 1694 -1696.
  • 6Zelensky AN, Greatly JE. The C-type lectin-like domain superfamily [J]. FEBSJ, 2005, 272(24): 6179-6217.
  • 7Hardison SE, Brown GD. C-type lectin receptors orchestrate antiftmgal immunity[J]. Nat lmmunol, 2012, 13(9) : 817 -822.
  • 8Wevers BA, Geijtenbeek TB, Gringhuis SI. C-type lectin receptors orchestrate antifungal immunity. [ J ]. Future Microbiol, 2013, 8(7) : 839 -854.
  • 9Wevers BA, Kaplein TM, Zijistra-Willer EM, et al. Fungal engagement of the C-type lectin mincle suppresses dectin-l-induced antifungal immunity. [J]. Cell Host Microbe, 2014, 15(4): 494-505.
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引证文献3

二级引证文献5

生命科学
2011年 第8期

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