摘要
采用测定大鼠胆汁分泌量的实验方法，观察栀子提取物京尼平苷和西红花苷十二指肠给药后的利胆作用。结果显示西红花苷５０和 １００ ｍｇ／ｋｇ剂量均不增加大鼠的胆汁流量，而京尼平苷５０和 １００ ｍｇ／ｋｇ剂量均可显著增加大鼠胆汁流量，降低胆汁内胆固醇含量，增加胆汁内 ＨＣＯ_３~－浓度．但对胆汁酸，胆红素，［Ｃａ^(２＋)］含量无显著影响。表明西红花苷没有利胆作用，而京尼平苷是栀子利胆的有效成分，它能改变胆汁成分，可能对阻止胆固醇结石的形成有一定的作用。
Effects of geniposide and crocins,the two extracts from Gardenia jasminoides Ellis, on the biliary secretion in rat were investigated. It was observed that, at the doses of 50mg/kg and 100mg/kg, geniposide could significantly increase the binary secretion after intraduodenal administration, while crocins showed no effect. On the other hand, geniposide can markedly decrease the content of cholesterol and elevate HCO_3^- concentration in bile, but without effect on the level of bilirubin, bile acid and Ca^(2+). The results show that geniposide is the main choleretic principle in Gardenia jasminoides Ellis.
出处
《中草药》
CAS
CSCD
北大核心
1999年第11期841-843,共3页
Chinese Traditional and Herbal Drugs
