摘要
目的明确遗忘型轻度认知障碍(amnesia-mild cognitive impairment,a-MCI)患者和轻度阿尔茨海默病(alzheimer's disease,AD)患者的认知损害特征。方法对13例a-MCI患者、22例轻度AD患者和37例正常对照进行全面的认知测查,除简易精神状态检查(mini-mental state examination,MMSE)外,测验可覆盖4个认知域:记忆力、信息处理速度、执行功能、视空间结构能力,进行组间比较。结果 3组患者在年龄、受教育程度及性别组成上匹配。轻度AD组的所有认知测验成绩都差于正常对照组,而且多数测验较a-MCI组也有减退。a-MCI组的MMSE、记忆相关测验以及多个执行功能相关测验结果都差于正常对照组,信息处理速度和视空间结构能力相关测验与对照组间无统计学差异。结论轻度AD患者表现为全面的认知功能减退。a-MCI患者除存在显著的记忆障碍外,还存在执行功能的异常,信息处理速度和视空间结构能力尚正常。
Objective To determine the cognitive profile of amnesia-mild cognitive impairment（a-MCI） and mild Alzheimer＇s disease（AD）.Methods In addition to the mini-mental state examination（MMSE）,extensive neuropsychological tests covering memory,executive function,mental processing speed,and visuoconstructive skill were performed on 13 a-MCI patients,22 mild AD patients,and 37 normal control subjects.The impaired domains in the 2 patient groups were determined.Results Mild AD group showed impairments in all cognitive domains.Compared with normal control subjects,a-MCI patients did worse in MMSE,memory assessments,and tests tapping executive function.No significant difference existed between a-MCI group and control group on evaluations for mental processing speed and visuoconstructive skills.Conclusion Current study indicated an overall cognitive decline in mild AD patients.While a-MCI mainly impaired in memory,they also showed deficit in executive function.A-MCI patients remain relatively normal in mental processing speed and visuoconstructive skills.
出处
《实用心脑肺血管病杂志》
2011年第9期1472-1474,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
遗忘型轻度认知障碍
阿尔茨海默病
认知特征
Amnesia-mild cognitive impairment
Alzheimer＇s disease
Cognitive profile
