摘要
目的探讨TK1、OPN与CEA在结直肠癌患者血清中的表达及临床意义。方法通过双抗体夹心酶联免疫吸附法(ELISA)检测结直肠癌患者术前血清及正常对照血清中TK1、OPN表达的变化,通过电化学发光法检测结直肠癌患者术前血清及正常对照血清中CEA表达的变化。结果结直肠癌患者血清中TK1、OPN与CEA的含量与正常对照组相比显著升高;血清TK1、OPN联合CEA诊断的阳性率较单一方法诊断的阳性率有显著提高(P<0.05)。结论血清中TK1、OPN、CEA均可作为结直肠癌的诊断指标,以CEA+TK1+OPN的联合检测诊断结直肠癌的临床价值最好。
Objective To investigate TK1、OPN and CEA in patients with colorectal carcinoma and its clinical significance.Methods To study the expression of TK1、OPN and CEA in the serum from the patients with colorectal carcinoma and healthy examination people.The concentration of TK1、OPN in the serum was detected by double antibody sandwich enzyme-linked immunosorbent,while the concentration of CEA were measured by electrochemical luminescence.Results The serum level of TK1、OPN and CEA in patients with colorectal carcinoma were higher than the common group,The combination of serum TK1、OPN and CEA increased the positive rate of diagnosis,which had significant difference with anyone（P0.05）.Conclusions Serum TK1、OPN and CEA could be used as diagnostic indicators of colorectal carcinoma,and combined determination of TK1、OPN and CEA showed the best clinical value.
出处
《社区医学杂志》
2011年第14期15-17,共3页
Journal Of Community Medicine
