摘要
目的探讨中期因子MK和CD105在下咽鳞状细胞癌组织中的表达及临床意义。方法采用免疫组织化学方法检测47例下咽鳞状细胞癌组织中MK的表达和CD105标记的微血管密度MVD情况,并根据检测结果分析与下咽癌各临床病理因素之间的关系。结果 MK的阳性表达率为68.08%,MK表达为阳性时CD105标记的MVD值(37.21±7.94)明显高于MK表达为阴性时的MVD值(25.11±7.94)(P<0.01),二者表达与临床分期、淋巴结转移有关。结论 MK及CD105标记的微血管密度(MVD)与下咽癌分期及淋巴结转移具有相关性,与下咽癌的分化程度无相关性,可作为一组有价值的肿瘤标记和预后指标。
Objective The expression of MK and CD105 in hypopharyngeal squamous cell tissues and their clinic significance.Methods The expression of MK in hypopharyngeal squamous cell carcinoma issues of 47 cases and MVD marked with CD105 were studied by immunohistochemical staining.According to the result of survey to analyze their relationships with clinical pathological features of hypopharyngeal carcinoma.Results The positive expression rate of MK is 68.08 %.MVD was significantly higher with both positive Mk in that with both negative Mk（37.23±5.44 VS 26.53±4.87）（P0.05）.the expression of MK and CD105 were all correlated with T-stage and lymph node metastasis.Conclusions MK and MVD marked with CD105 were all associated with T-stage of hypopharyngeal carcinoma and lymph node meatstasis.The progress of hypopharyneal carcinoma was indepengent,they can be as valuable tumor maker and prognostic factor for hypopharyngeal aquamous cell carcinoma.
出处
《社区医学杂志》
2011年第14期6-8,共3页
Journal Of Community Medicine
关键词
下咽癌
中期因子
CD105
MVD
Hypopharyngeal carcinoma
Midkine
CD105
microvesseldensity
