摘要
用高分子亲水性胶体作为主要骨架材料制备了硫酸锌骨架型缓释片SR-1 SR-2,用普通片C-T作对照,测定了SR-l、SR-2及C-T片的体外溶出累计百分率。用溶出速度参数T_(50)作比较,SR-1,SR-2的缓释作用分别为普通片的4.7倍和2.8倍。锌含量测定采用锌试剂(zincon)紫外分光光度方法。
Two kinds of zinc sulfate(ZS) sustained release tablets (SR-1, SR-2) were prepared by usingpolymolecular hydrophilic colloid as the major matrix materials. Dissolution studies of zinc ionfrom SR-1, SR-2 and conventional tablet (C-T) were carried out by rotary-basket method. TheT_(50) of SR-1, SR-2 and C-T tablets were respectively 14.35±1.39, 8.63±1.53 and 3.03±0.49minutes Significant differences existed among the three tablets (P<0.001). The violet color produced by the reaction of zinc ion with zincon was used in analysingthe contents of three tablets by spectrophotometry at 620 nm.
关键词
硫酸锌
缓释片
紫外光度法
锌试剂
Zinc sulfate
Sustained release tablet
Conventional tablet
UV spectrophotometry zincon.
