摘要
目的探讨影响骨恶性纤维组织细胞瘤生存率、局部复发和远处转移的危险因素。方法1997年7月至2010年7月共有56例骨恶性纤维组织细胞瘤患者接受治疗。对年龄、性别、肿瘤部位、肿瘤大小等9项可能影响预后的因素进行回顾性单因素和多因素分析。结果44例患者获得随访，平均随访时间33．3个月（2周～78个月）。5年总体生存率为50．1％，局部复发率为40．9％，局部复发中位时间12个月（3～60个月），术后转移发生率27．5％（11／40），中位转移时间为6．5个月（2～23个月）。单因素分析结果表明，性别、就诊情况（初治和复发）、肿瘤部位、外科边界以及肿瘤分期与生存率有相关性（P〈0．05），外科边界、肿瘤部位与局部复发有相关性（P〈0．05），侵犯重要血管神经（有或无）与远处转移有相关性（P〈0．05）；多因素分析显示，外科边界、肿瘤分期是影响生存率的独立危险因素，外科边界是影响局部复发的独立危险因素。结论外科边界、肿瘤分期是影响生存率的独立危险因素，外科边界是影响局部复发的独立危险因素。
Objective To study the risk factors related to the survival rate, recurrence and metastasis of malignant fibrous histiocytoma of bone. Methods From July 1997 and July 2010, 56 patients with malignant fibrous histiocytoma of bone were treated. Univariate and multivariate analysis were performed to determine the probable risk factors including gender, age, tumor location, tumor size and so on. Results Forty-four cases were followed up ranged from 2 weeks to 78 months （ medium 33.3 ）. The 5-year overall survival rate was 50. 1% , local reccurence rate 40. 9% with a median time of 12 months （3 to 60 months） and metastatic rate 27.5 % （ 11/40 ）with a median time of 6. 5 months （2 to 23 months ）. Univariate analysis indicated that gender, condition of presentation （ primary case or recurrence case） , tumor location, surgical margin and surgical stage were significantly related to survival rate （ P 〈 0.05 ）, and tumor location and surgical margin were related to local recurrence rate （P 〈 0. 05 ）, and important vessel or nerve invasion was related to metastatic rate（P 〈 0. 05）. Multivariate analysis showed that surgical margin and surgical stage were independent risk factors for survival rate, of which surgical margin was the independent risk factor for recurrence rate. Conclusions Surgical margin and surgical stage are independent risk factors for survival rate, of which surgical margin is the independent risk factor for recurrence rate.
出处
《中华外科杂志》
CAS
CSCD
北大核心
2011年第8期733-736,共4页
Chinese Journal of Surgery
关键词
组织细胞瘤
恶性纤维
骨肿瘤
生存率
复发
转移
预后
Histiocytoma, malignant fibrous
Bone, neoplasms
Survival rate
Recurrence
Metastasis
Prognosis
