摘要
目的观察脑恶性胶质瘤采用尼莫司汀经动脉超选化疗的疗效及安全性。方法回顾性分析64例脑恶性胶质瘤病人的临床资料,其中多形性胶质母细胞瘤38例,间变性星形细胞瘤22例,胶质肉瘤4例。显微镜下尽量切除肿瘤,术后采用尼莫司汀(2.5 mg/kg)行经动脉超选化疗。结果肿瘤全切除56例,大部分切除6例,部分切除2例。所有病例随访3～18个月,平均8个月。术后复发8例(12.50%),其中再次手术2例。化疗前后KPS评分差异无统计学意义(P>0.05)。出现不同程度骨髓抑制40例(62.50%);胃肠道反应4例(6.25%);未见与介入操作相关的并发症、肝肾功能改变、眼部及神经系统并发症。结论脑恶性胶质瘤采用尼莫司汀经动脉超选化疗是一种安全、有效的辅助治疗方法,值得进一步研究。
Objective To observe therapeutic efficacy and safety of intra-arterial superselective chemotherapy with nimustine in the treatment of malignant brain glioma.Methods The clinical data of 64 patients with malignant brain glioma,including 38 with glioblastoma multiforme,22 with anaplastic astrocytoma and 4 with gliosarcoma,were analyzed retrospectively.All the patients underwent intra-arterial superselective chemotherapy with nimustine（2.5mg/kg） after the resection of tumor under the microscope.Results Total removal of the tumor was achieved in 56 patients,subtotal removal in 6 and partial removal in 2.All the patients were followed up for 3 to 18 months with a mean of 8 months.The postoperative recurrence occurred in 8 patients（12.50%）,2 of whom underwent reoperation.No statistical difference was found between KPS scores before and after chemotherapy（P0.05）.Myelosuppression to different degrees was observed in 40 patients（62.50%） and gastrointestinal reaction in 4（6.25%）.No ophthalmic,nervous system and intervention operation-related complications occurred.No hepatorenal dysfunction was found.Conclusions Intra-arterial superselective chemotherapy with nimustine is a safe and effective for patients with malignant brain glioma and merits further study.
出处
《中国微侵袭神经外科杂志》
CAS
北大核心
2011年第8期337-339,共3页
Chinese Journal of Minimally Invasive Neurosurgery
基金
上海市科委重点科技攻关资助项目(编号:08411953600)
关键词
神经胶质瘤
化疗
超选择性
动脉内灌注
glioma
chemotherapy
superselective
intra-arterial infusion
