摘要
目的评价川芎嗪注射液治疗糖尿病肾病(DN)的有效性和安全性。方法计算机检索PubMed、Cochrane Library、EMbase及中国生物医学文献数据库(CBM)、中国学术期刊全文数据库(CNKI)、中文科技期刊数据库(VIP)、中国生物医学期刊文献数据库(CMCC),全面收集有关川芎嗪注射液治疗DN的随机对照试验,按照Cochrane Library Handbook推荐的质量评价方法评价纳入研究的质量,符合纳入标准的研究用RevMan 5.0软件对数据进行Meta分析。结果共纳入9篇随机对照试验,包括492例DN患者。Meta分析结果显示:与常规治疗组相比,联用川芎嗪组可降低DN患者24 h尿清蛋白排泄率[MD=-62.04,95%CI(-95.46,-28.63)]、血清肌酐[MD=-28.94,95%CI(-47.78,-10.09)]、24 h尿白蛋白排泄率、24 h尿白蛋白总量及24 h尿蛋白定量[MD=0.53,95%CI(-0.82,-0.24)],但对血尿氮素[MD=-1.16,95%CI(-2.63,0.30)]、舒张压及收缩压等降低不明显。所有纳入研究未发现严重的不良反应。结论现有研究表明川芎嗪注射液治疗DN有一定疗效,且无明显不良反应。但纳入研究数量偏少,质量偏低,论证强度不够,应开展设计严格的随机双盲对照试验,为川芎嗪注射液治疗DN提供更可靠的证据。
Objective To evaluate the effectiveness and safety of Ligustrazine injection for treating diabetic nephropathy（DN）.Methods Randomized controlled trials（RCTs） on Liviprazine in treatment of DN were searched in PubMed,EMbase,Cochrane Library,CMCC,VIP,CNKI,CBM.Data were strictly extracted using the fundamental evaluation method recommended in Cochrane Handbook and Meta-analysis was performed using Rev Man 5.0 software.Results Nine RCTs of 492 patients of DN were included,but their methodological quality was low.Meta-analysis showed that：compared with basic therapy,Liviprazine injection was superior to routine treatment in decreasing the 24 h-UTP [MD=0.53,95%CI（-0.82,-0.24）],24 h-VAER [MD=-62.04,95%CI（-95.46,-28.63）],SCr [MD=-28.94,95%CI（-47.78,-10.09）],24 h-UAER and 24-UAlb,and Liviprazine had similar effects in reducing BUN [MD=-1.16,95%CI（-2.63,0.30）],DBP,SBP,et al.No serious side effects were observed during the treatment period.Conclusion The researches currently available show that Liviprazine injection has some effect in treating patients with DN and has no obvious side effects.However,the evidence is insufficient to determine the effects of Liviprazine due to low-quantity and low-quality trials.Double-blinded RCTs are needed to assess the effects and relatively safe of Ligustrazine injection for DN.
出处
《中国中医药信息杂志》
CAS
CSCD
2011年第8期26-29,共4页
Chinese Journal of Information on Traditional Chinese Medicine
基金
甘肃省自然科学基金(0916RJZA007)
关键词
川芎嗪注射液
糖尿病肾病
随机对照试验
系统评价
Ligustrazine injection； diabetic nephropathy； randomized controlled trial； systematic review；
