摘要
采用双抗夹心酶联免疫吸附试验（ＥＬＩＳＡ）测定了３４ 例急性脑梗塞患者发病后２４ 小时、７２小时、１ 周及２ 周的血清可溶性细胞间粘附分子－１（ｓＩＣＡＭ－１）浓度。结果示发病１ 周内ｓＩＣＡＭ－１浓度逐渐上升，于１ 周时达高峰，２ 周后明显下降。发病后７２ 小时ｓＩＣＡＭ－１ 水平与脑梗塞体积呈正相关（Ｐ＜０．０１）；但与病情严重程度无明显相关关系（Ｐ＞ ０．０５）。认为ｓＩＣＡＭ－１ 在急性脑梗塞病程中呈动态变化，ｓＩＣＡＭ－１ 参与了脑梗塞的病理发展过程；血清ｓＩＣＡＭ－１ 浓度可作为监测急性脑梗塞白细胞介导的脑损伤的一个指标，与脑梗塞体积呈正相关。
The levels of serum cellular adhesion molecules in 34 patients with acute ischemic stroke after the onset of cerebral infarction at 24 hours,72 hours,7 days,and more than 14 days were determined by ELISA The result showed that the levels of sICAM 1 increased during the first week after the onset of acute ischemic stroke and dramatically decreased after two weeks. There was a positive correlation between levels of sICAM 1 and the volume of infarction in 72 hours(r=0.6326,P<0.01),but there was no such relationship between levels of sICAM 1 and the severity of the disease(P> 0.05 ).The results indicate that the acute changes of sICAM 1 levels in response to acute ischemic stroke.ICAM 1 probably take part in the pathologival process of acute ischemic stroke and could be responsible for adhesion and activation of leukocytes at sites of tissue irritation and subsequent transendothelial migration of leukocytes into damaged tissue.Determination of sICAM 1 could allow in vivo monitoring of the initial steps of leukocyte mediated brain damage in acute ischemic stroke.
出处
《山东医药》
CAS
北大核心
1999年第21期1-3,共3页
Shandong Medical Journal
关键词
急性
脑梗塞
血清
SICAM-1
Cerebral ischemic Soluble intercellular adhesion molecule 1 Leukocyte
