摘要
良性前列腺增生症(BPH)可能因细胞凋亡减少而形成。绝大多数细胞凋亡均需通过半光天冬酶(caspase)这一类特异酶。BPH的发生与新生血管形成(anglogenesis)有关,血管内皮素可能控制器官的体积。内抑制素(endostatin)及血管抑制素(angiostatin)可抑制新生血管的形成,故可用以治疗肿瘤及BPH。药物治疗应作为BPH的第一线治疗,联合应用5α-还原酶抑制剂非那雄胺(finasteride)及α_(1A)-AR阻断剂可增加BPH细胞凋亡。
Delayed apop tosis may beone of BHP' s cause, specific apoptotic enzymes caspase 3 and caspase 7 have been found in the prostate. Survivin(IAP) can block the apoptosis induced by caspase, Bax, Fas -Fasl, and the effect of anticancer drugs in 60 kinds of carcinoma. It is a kind of embryonic protein structurally similar to P35 of bac-ulovirus. This survivin may play a critical role in the pathogenesis of BPH. Folkman (1998) found that BPH is also angiogenesis dependent Alpha -blockers and finasteride have been discussed in detail.
关键词
前列腺增生
药物疗法
良性
apoptosis, caspase, survivin, IAP, angiogenesis,α-blocker, finasteride
