不同剂量阿司匹林对脑梗死并高血压患者hs-CRP、PAG及生活能力的影响被引量：6

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摘要目的探讨不同剂量阿司匹林(ASP)对脑梗死(C I)并高血压患者血清高敏-C反应蛋白(hs-CRP)、血小板聚集率(PAG)及生活能力的影响。方法将90例C I并高血压患者随机分为ASP 75 mg组(A组)、100 mg组(B组)、300 mg组(C组),检测三组治疗前后血清hs-CRP、PAG及Barthel指数(B I)变化,并与正常对照组比较。结果治疗前,A、B、C组hs-CRP及PAG均明显高于对照组(P<0.01)。治疗4周后,hs-CRP、PAG降低幅度C组>B组>A组(P<0.05或<0.01);6个月后,PAG C组低于B组(P<0.01);B I C组>B组>A组(P均<0.01)。结论 C I并高血压患者血清hs-CRP、PAG明显升高,ASP治疗4周后其改善状况300 mg/d>100 mg/d>75 mg/d,长期服药对hs-CRP、PAG无明显影响,阿司匹林75 mg/d即可达到预期效果。

作者姚立军方琪

机构地区苏州大学附属第一医院

出处《山东医药》 CAS 北大核心 2011年第25期36-37,共2页 Shandong Medical Journal

关键词脑血管疾病高血压阿司匹林 C反应蛋白质血小板聚集率

分类号 R743 [医药卫生—神经病学与精神病学]

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