摘要
目的:探讨原发性高血压患者血管紧张素Ⅱ(AngⅡ)与左心室肥厚(LVH)的相关性。方法:对2009年4月至2010年12月,高血压科住院行超声心动图(UCG)检查及其他临床资料完整的581例患者,进行回顾性分析;并通过二维引导的M-模式进行测量记录左心室结构,左心室质量指数(LV-MI),将高血压患者分为高血压伴LVH组(LVH组,n=100)和高血压不伴LVH组(NLVH组,n=481),分析AngⅡ与LVH间的相关性。结果:LVH组体质量指数、收缩压、脉压、肌酐(Scr)、肾素及AngⅡ均高于NLVH组(P<0.001)。以LVH为因变量,以收缩压、脉压、Scr及AngⅡ为自变量进行logistic回归分析,显示收缩压、脉压、Scr及AngⅡ与LVH相关,差异有统计学意义(P<0.05)。结论:收缩压、脉压、Scr及AngⅡ在原发性高血压患者左心室肥厚的发生发展过程中起重要作用。
Objective：To investigate the relevance of angiotension Ⅱ and left ventricular hypertrophy in patients with essential hypertension.Methods： The clinical date of hypertension inpatients from April 2008 to Dec.2010 were reviewed for retrospective analysis,of which 581 cases underwent echocardiography（UCG） and other examination so as to keep clinical data integrity.By two-dimensional guided M-mode recording,left ventricular structure and left ventricular mass index（LVMI）=LVM/body surface area（m2 were measured.The hypertensive patients were divided into two groups of hypertension with LVH（LVH group,n=100） and hypertension not accompanied by LVH group（NLVH group,=481）,so as to investigate the relevance of angiotension Ⅱ between two groups.Results： Compared with NLVH group,LVMI,systolic blood pressure,pulse pressure,creatinine（Cr）,AngⅡ were higher in LVH group,and the difference was statistically significant（P0.001）.With LVH as the dependent variable,systolic blood pressure,pulse pressure,Scr and AngⅡ as the independent variable,logistic regression analysis showed that systolic blood pressure,pulse pressure Scr and AngⅡ were associated with LVH（P0.05）,and the date were statistically significant.Conclusion： the systolic blood pressure,pulse pressure,Scr and angiotensin play important roles in the development process of left ventricular hypertrophy in patients with essential hypertension.
出处
《心肺血管病杂志》
CAS
2011年第4期290-292,共3页
Journal of Cardiovascular and Pulmonary Diseases
关键词
原发性高血压
血管紧张素Ⅱ
左心室肥厚
超声心动图
Essential hypertension
AngiotensinⅡ
Left ventricular hypertrophy
Echocardiography
