摘要
目的探讨VAD方案和VTD方案治疗初治多发性骨髓瘤的疗效。方法回顾性分析43例初治多发性骨髓瘤患者的治疗情况,其中VAD治疗组24例,VTD治疗组19例。结果 VAD治疗组有效率62.5%(15/24),VTD治疗组有效率68.4%(13/19),两治疗组疗效差异无统计学意义(P>0.05)。不良反应中,心脏毒性发生率VAD治疗组高于VTD治疗组,差异有统计学意义(P<0.05)。结论对于伴有心脏功能异常的初治多发性骨髓瘤患者应首选VTD方案治疗。
Objective To investigate the therapeutic effect of VAD and VTD regimens in the initial treatment of patients with multiple myeloma（MM）. Methods Forty-three untreated patients with multiple myeloma were initially treated with VAD（n=24） or VTD（n=19） regimen,the outcome of patients was retrospectively analyzed. Results The effective rate was 62.5% in patients receiving VAD regimen,and 68.4% in patients receiving VTD regimen（P0.05）.The incidence rate of heart toxicity in VAD group was higher than that in VTD group（P0.05）. Conclusion VTD regimen should be the first choice for untreated MM patients with cardiac dysfunction.
出处
《实用肿瘤杂志》
CAS
北大核心
2011年第4期403-405,共3页
Journal of Practical Oncology
