摘要
目的 :研究微量元素与 2型糖尿病的关系。方法 :对 40例 2型糖尿病患者血清锌、铜、铬、硒、铁、钙、镁 7种元素加以测定 ,并与正常健康对照组 30例相比较。全部数据均采用 Spss7.5统计分析软件处理。结果 :2型糖尿病患者血清锌、铬、硒明显低于对照组 ,( P分别 <0 .0 5,<0 .0 1 ) ;血清铜、铜 /锌比值显著高于对照组 ( P<0 .0 1 ) ;血清铁、钙、镁两组无差异。单因素相关分析显示 :2型糖尿病患者血清锌、硒、铬元素含量与血糖呈负相关 ,血清铜、铜 /锌比值与血糖呈正相关 ,各微量元素含量与糖化血红蛋白 Hb A1c均无显著相关关系。多元回归分析 ,与血糖关系最密切的微量元素依次为血清硒、铬和铜 /锌比值。结论 :血清微量元素确实与糖尿病有密切的关系 ,当中尤以低血硒、低血铬、高铜 /锌比值是影响糖尿病病情及其并发症的重要因素。提示在糖尿病病人中应注意微量元素的补充 。
Objective: To investigate the relationship between trace element and diabetes mellitus Methods: To measure the 7 kinds of serum trace elements including Zn,Cu,Cr,Se,Fe, Ca,Mg in 40 patients with type 2 DM and compare with 30 healthy controls All date were analysised by Spss 7 5 statistical software Results: Serum Zn, Cr, Se in type 2 DM group was significantly lower than that in control group ( P <0 05), and serum Cu,Cu/Zn was significantly higher than control group ( P <0 01) There was no difference in serum Fe,Ca,Mg Monofactorial relative analysis showed that there was a negative correlation of serum Zn,Se,Cr with blood glucose, and positive correlation of serum Cu,Cu/Zn with blood glucose Serum trace element level was not related to hemoglobin A1c Mutiple stepwise regression analysis demonstrated that serum Se,Cr,Cu/Zn were significantly related to blood glucose Conclusion: The relation of trace elements to DM were rather close In these elements, Se,Cr and Cu/Zn were most closely related to blood glucose level Patients with diabetes should increase the intake of Se,Cr, Zn, it was useful for prevention and treatment of DM and its complications
出处
《天津医科大学学报》
1999年第4期60-62,共3页
Journal of Tianjin Medical University
