摘要
目的比较地特胰岛素(诺和平)联合门冬胰岛素(诺和锐)与胰岛素泵持续皮下输注(continuoussubcutaneous insulin infusion,CSII)对初发2型糖尿病胰岛功能的影响。方法将新诊断的2型糖尿病患者随机分为两组:分次注射组(n=20)和CSII组(n=20),分别给予地特胰岛素联合门冬胰岛素和胰岛素泵治疗2周。治疗前后均进行口服葡萄糖试验,测定空腹和2 h血糖和血浆C肽,比较治疗前后血糖水平及血浆C肽的变化。结果两组治疗后均较治疗前血糖显著下降(P<0.01),血浆C肽均明显升高(P<0.05)。治疗后两组间比较血糖和血浆C肽无显著差异(P>0.05)。结论地特胰岛素联合门冬胰岛素治疗初发2型糖尿病与胰岛素泵强化治疗血糖控制水平和改善胰岛功能的作用相当。
Objective To compare the effect of insulin detemir plus insulin aspart（detemir＋aspart,）and insulin pumps（continuous subcutaneous insulin infusion,CSII）on β-cell function of the patients newly diagnosed as type 2 diabetes mellitus.Methods Forty cases of the newly diagnosed type 2 diabetes mellitus were randomly assigned into two groups： detemir plus aspart group（n=20）,insulin pump group（n=20）.All patients were treated for 2 weeks.Before and after treatment,the oral glucose tolerance test was conducted to detect the level of C-peptied,blood glucose.Results After treatment,the blood glucose levels significantly decreased in two groups（P0.01）.The blood C-peptied levels,two groups were significantly higher after treatment than that before treatment（P0.05）.All indices showed no significant difference between two groups（P0.05）.Conclusion Detemir plus aspart could improve β-cell function of patients with the newly diagnosed type 2 diabetes mellitus,with the same efficacy as insulin pumps.
出处
《黑龙江医学》
2011年第7期493-494,共2页
Heilongjiang Medical Journal
